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Health, nutrition, and development of children born preterm and low birth weight in rural Rwanda: a cross-sectional study

机译:卢旺达农村地区早产和低出生体重儿的健康,营养和发育:一项横断面研究

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As care for preterm and low birth weight (LBW) infants improves in resource-limited settings, more infants are surviving the neonatal period. Preterm and (LBW) infants are at high-risk of nutritional and medical comorbidities, yet little is known about their developmental outcomes in low-income countries. This study evaluated the health, nutritional, and developmental status of preterm/LBW children at ages 1–3?years in Rwanda. Cross-sectional study of preterm/LBW infants discharged between October 2011 and October 2013 from a hospital neonatal unit in rural Rwanda. Gestational age and birth weight were gathered from hospital records to classify small for gestational age (SGA)?at birth and prematurity. Children were located in the community for household assessments in November–December 2014. Caregivers reported demographics, health status, and child development using locally-adapted Ages and Stages Questionnaires (ASQ-3). Anthropometrics were measured. Bivariate associations with continuous ASQ-3 scores were conducted using Wilcoxon Rank Sum and Kruskal Wallis tests. Of 158 eligible preterm/LBW children discharged from the neonatal unit, 86 (54.4%) were alive and located for follow-up. Median birth weight was 1650?grams, median gestational age was 33?weeks, and 50.5% were SGA at birth. At the time of household interviews, median age was 22.5?months, 46.5% of children had feeding difficulties and 39.5% reported signs of anemia. 78.3% of children were stunted and 8.8% wasted. 67.4% had abnormal developmental screening. Feeding difficulties (p?=?0.008), anemia symptoms (p?=?0.040), microcephaly (p?=?0.004), stunting (p?=?0.034), SGA (p?=?0.023), very LBW (p?=?0.043), lower caregiver education (p?=?0.001), and more children in the household (p?=?0.016) were associated with lower ASQ-3 scores. High levels of health, growth, and developmental abnormalities were seen in preterm/LBW children at age 1–3?years. As we achieve necessary gains in newborn survival in resource-limited settings, follow-up and early intervention services are critical for ensuring high-risk children reach their developmental potential.
机译:随着对早产儿和低体重儿的护理在资源有限的环境中得到改善,越来越多的婴儿幸存下来。早产儿和(LBW)婴儿处于营养和医学合并症的高风险中,但对于低收入国家的发育结果知之甚少。这项研究评估了卢旺达1至3岁儿童早产/体重不足儿童的健康,营养和发育状况。卢旺达农村地区2011年10月至2013年10月间从医院新生儿室出院的早产/低体重儿的横断面研究。从医院记录中收集了胎龄和出​​生体重,对出生和早产中的胎龄小(SGA)进行了分类。儿童于2014年11月至12月在社区中进行家庭评估。看护人使用当地适应的年龄和阶段问卷(ASQ-3)报告了人口统计学,健康状况和儿童发育情况。测量了人体测量学。使用Wilcoxon Rank Sum和Kruskal Wallis检验进行连续ASQ-3评分的双变量关联。从新生儿单元出院的158名合格早产/低出生体重儿童中,有86名(54.4%)仍活着并需要随访。出生时的中位体重为1650克,胎龄中位数为33周,出生时的SGA为50.5%。在家庭访问时,中位年龄为22.5个月,有46.5%的儿童有进食困难,39.5%的人报告有贫血迹象。 78.3%的儿童发育迟缓,8.8%的儿童浪费。 67.4%的儿童发育筛查异常。喂养困难(p = 0.008),贫血症状(p = 0.040),小头畸形(p = 0.004),发育迟缓(p = 0.034),SGA(p = 0.023),极低体重p?=?0.043),较低的看护者教育水平(p?=?0.001)和家庭中更多的孩子(p?=?0.016)与ASQ-3得分较低相关。在1-3岁的早产/低体重儿童中发现了较高水平的健康,生长和发育异常。当我们在资源有限的环境中实现新生儿生存的必要增长时,随访和早期干预服务对于确保高危儿童发挥其发展潜力至关重要。

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