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首页> 外文期刊>BMC Pediatrics >Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial
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Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial

机译：一项集群随机试验：含有少量锌的小量基于脂质的营养补品以及腹泻和疟疾治疗可提高铁和维生素A的状况，并降低贫血患病率，但不影响锌的状况。

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Background We assessed the effects of providing a package of interventions including small-quantity lipid-based nutrient supplements (SQ-LNS) containing 0, 5 or 10?mg zinc and illness treatment to Burkinabe children from 9 to 18 months of age, on biomarkers of zinc, iron and vitamin A status at 18 months and compared with a non-intervention cohort (NIC). Methods Using a two-stage cluster randomized trial design, communities were randomly assigned to the intervention cohort (IC) or NIC, and extended family compounds within the IC were randomly assigned to different treatment groups. IC children ( n =?2435) were provided with 20?g SQ-LNS/d containing 0, 5 or 10?mg zinc, 6?mg of iron and 400?μg of vitamin A along with malaria and diarrhea treatment. NIC children ( n =?785) did not receive the intervention package. At 9 and 18 months, hemoglobin (Hb), zinc, iron and vitamin A status were assessed in a sub-group ( n =?404). Plasma concentrations of zinc (pZC), ferritin (pF), soluble transferrin receptor (sTfR) and retinol-binding protein (RBP) were adjusted for inflammation. Results At baseline, 35% of children had low adjusted pZC (8.3?mg/L) and 47% had low adjusted RBP (Conclusions SQ-LNS regardless of zinc amount and source provided along with illness treatment improved indicators of iron and vitamin A status, but not pZC. Trial registration NCT00944281 (July 21, 2009).
机译：背景我们评估了对一整套生物标志物的干预措施的效果，这些干预措施包括含0、5或10 mg锌的小剂量脂质基营养补充剂（SQ-LNS）以及9至18个月大的布基纳法索儿童疾病治疗18个月时锌，铁和维生素A的状况，并与非干预队列（NIC）进行比较。方法采用两阶段集群随机试验设计，将社区随机分配至干预队列（IC）或NIC，并将IC中的扩展家族化合物随机分配至不同的治疗组。患有IC病的儿童（n =？2435）被提供了20？g SQ-LNS / d，其中包含0、5或10？mg的锌，6？mg的铁和400？g的维生素A，以及疟疾和腹泻的治疗方法。 NIC儿童（n =？785）未收到干预措施。在9和18个月时，评估了一个亚组的血红蛋白（Hb），锌，铁和维生素A的状态（n = 404）。调节血浆中锌（pZC），铁蛋白（pF），可溶性转铁蛋白受体（sTfR）和视黄醇结合蛋白（RBP）的浓度以应对炎症。结果基线时，35％的儿童的pZC值较低（8.3？mg / L），47％的RBP值较低（结论SQ-LNS不论锌的量和来源如何，以及疾病治疗如何改善铁和维生素A状况指标，而不是pZC。试用注册号NCT00944281（2009年7月21日）。

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