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首页> 外文期刊>BMC Pediatrics >Incidence and time trends of type 2 diabetes mellitus in youth aged 5–19 years: a population-based registry in Zhejiang, China, 2007 to 2013
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Incidence and time trends of type 2 diabetes mellitus in youth aged 5–19 years: a population-based registry in Zhejiang, China, 2007 to 2013

机译：5至19岁年轻人中2型糖尿病的发病率和时间趋势：基于人群的中国浙江省登记处，2007年至2013年

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Background The incidence of type 2 diabetes mellitus (T2DM) has been increasing globally over the past two decades in children and adolescents. There are currently a dearth of comprehensive population-based estimates of T2DM incidence and time trends in Chinese youth. Methods A population-based diabetes registry system in 30 representative districts in Zhejiang has been established for diabetes surveillance. All newly cases diagnosed by physicians in local hospitals and wards were registered using the registry system through web services and direct network report. The data were primarily ed from medical records in hospitals and wards. Annual incidence rates and their 95% confidence intervals (CIs) by age groups and sex were calculated per 100 000 person-years. Poisson regression models were applied to assess the effects of diagnosis year, age groups, sex and residence area on T2DM incidence and to examine the average annual percentage change in incidence. Results There were 392 newly diagnosed cases of T2DM (210 boys and 182 girls) over the study period. The mean annual age-standardized incidence was 1.96/100 000 person-years (95% CIs: 1.85–2.08). No statistically significant difference in incidence was found between boys and girls. However, the risk for T2DM was 1.49 times higher in urban area than in rural area. Besides, the mean annual incidence in youth increased with age. The age-standardized incidence was about 5 times higher in 2013 than in 2007. Steep rising incidence was observed, with an average annual increase of 26.6% in youth aged 10–19 years. Conclusions The incidence of T2DM in children and adolescents was low in Zhejiang relative to other countries, whereas it increased markedly over the study period. Preventive strategies for T2DM are necessary in pediatric population.
机译：背景技术在过去的二十年中，儿童和青少年的2型糖尿病（T2DM）发病率在全球范围内一直在增加。目前尚缺乏基于人群的中国青年人T2DM发病率和时间趋势的综合估计。方法在浙江省30个代表区建立了以人群为基础的糖尿病登记系统，对糖尿病进行监测。本地医院和病房的医生诊断出的所有新病例都通过网络服务和直接网络报告使用注册系统进行注册。数据主要来自医院和病房的医疗记录。每10万人年计算出的年发病率及其按年龄组和性别划分的95％置信区间（CI）。使用泊松回归模型评估诊断年，年龄组，性别和居住地区对T2DM发病率的影响，并检查发病率的年均百分比变化。结果在研究期间，共有392例新诊断的T2DM病例（男210例，女182例）。年龄标准化的平均年发病率为1.96 / 100 000人年（95％CI：1.85–2.08）。男孩和女孩之间的发病率没有统计学上的显着差异。但是，城市地区T2DM的风险是农村地区的1.49倍。此外，青年的年平均发病率随年龄增长。 2013年，以年龄为标准的发病率比2007年高出约5倍。观察到发病率急剧上升，在10至19岁的青年中，年均增长26.6％。结论浙江省儿童和青少年的T2DM发病率相对于其他国家而言较低，但在研究期间却显着增加。小儿T2DM的预防策略是必要的。

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