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首页> 外文期刊>BMC Pediatrics >Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso
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Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

机译：布基纳法索儿童先天性畸形和与口腔颌面裂相关的医疗条件

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Background Orofacial clefts are usually isolated cases but can be associated with other congenital malformations that are either recognised or unrecognised syndromes. The reported prevalence and pattern of such associated malformations, however, vary among studies. Objectives: To assess the frequencies and aetiologies of congenital malformations and associated medical conditions in children with orofacial clefts in Burkina Faso (Western Africa). Methods A retrospective descriptive study was carried out at the El Fateh-Suka Clinic in Ouagadougou, Burkina Faso. All children who attended surgery for the repair of a cleft lip and/or palate were included in this study. Results The frequency of congenital malformations associated with cleft lip and/or palate was 39/185 (21.1%). In the group with multiple congenital malformations of unknown origin (34 patients; 18.4%), 66.7% had cleft lip and palate, followed by isolated cleft lip (27.4%) and isolated cleft palate (5.9%). The digestive system (35.3%), the musculoskeletal system (19.6%), and eye, ear, face, and neck (15.7%) were the most affected systems. In the group of syndromic malformations (five patients; 2.7%), amniotic band syndrome (one patient), Van der Woode syndrome (one patient), Goltz syndrome (one patient), and holoprosencephaly (two patients) were identified. Medical conditions included anaemia (39.4%), infections (9.2%), malnutrition (7.5%), and haemoglobinopathies (4.3%). Conclusions Congenital malformations and medical co-morbidities were frequent in children with OFCs. Further studies and a National Malformations Registry are needed to improve the comprehension of OFCs in Burkina Faso.
机译：背景口面部裂痕通常是孤立的病例，但也可能与其他先天性畸形有关，这些畸形是公认的或无法识别的综合征。然而，报道的这种相关畸形的患病率和模式在研究之间有所不同。目的：评估布基纳法索（西非）口面部裂口儿童先天性畸形的频率和病因以及相关的医疗状况。方法在布基纳法索瓦加杜古的El Fateh-Suka诊所进行了回顾性描述性研究。所有参加手术治疗唇裂和/或pa裂的儿童均纳入本研究。结果先天性畸形与唇裂和/或pa裂相关的频率为​​39/185（21.1％）。在具有多个未知来源的先天性畸形的组中（34例; 18.4％），有66.7％的唇c裂，其次是孤立的唇裂（27.4％）和孤立的left裂（5.9％）。消化系统（35.3％），肌肉骨骼系统（19.6％）以及眼，耳，脸和脖子（15.7％）是受影响最大的系统。在综合征性畸形组（5例; 2.7％）中，鉴定出羊膜带综合征（1例），范德伍德综合征（1例），戈尔茨综合征（1例）和全前脑畸形（2例）。医学状况包括贫血（39.4％），感染（9.2％），营养不良（7.5％）和血红蛋白病（4.3％）。结论OFC患儿先天性畸形和内科合并症多发。需要进一步研究和建立国家畸形登记处以提高对布基纳法索的OFC的理解。

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