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首页> 外文期刊>BMC Physiology >Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats
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Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats

机译：在MLSS周围进行的运动可降低高血压大鼠的收缩压并增加有氧运动

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Background Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in spontaneously hypertensive rats (SHRs) as an important step in establishing secure intensities for prescribing exercise for hypertensive phenotypes. Here we verified the effects of training around MLSS, 20% below MLSS, and 15% above MLSS on aerobic fitness and blood pressure status of SHR. Eighteen-week-old SHRs (n?=?5, ~ 172.4?±?8.1?mm Hg systolic blood pressure) were trained on a treadmill for 4?weeks for 30?min/day, 5?days/week at a velocity of 20?m.min?1. After training, a novel MLSS and incremental test was performed to evaluate the animals’ aerobic fitness. Furthermore, ~ 22-week-old SHRs (n?=?12, ~169.8?±?13.8?mm Hg systolic blood pressure) were divided into non-exercised (CG, n?=?4), low intensity (LIG, n?=?4) and high intensity (HIG, n?=?4) groups, where rats were trained at 16?m.min?1 and 23?m.min?1 respectively for 30?min/day, 5?days/week for 4?weeks. Results Exercise performed at MLSS enhanced aerobic fitness, leading to a novel MLSS, identified around 30?m.min?1. Low and high intensity training reduced systolic blood pressure and only high intensity training led to improved aerobic fitness (28.1%, p? Conclusions Therefore, our data indicate a decrease in blood pressure due to low and high exercise intensity, and an increase in aerobic fitness provided by high-intensity exercise in SHRs.
机译：背景技术运动是一种广泛用于控制高血压的非药物制剂，其中低强度通常与血压降低有关。最近在自发性高血压大鼠（SHRs）中确定了最大乳酸稳态（MLSS），这是确定处方强度运动处方安全强度的重要步骤。在这里，我们验证了围绕MLSS进行的训练对SHR的有氧适应性和血压状态的影响，其中MLSS低于MLSS 20％，MLSS高于15％。在跑步机上训练18周龄SHR（n？=？5，〜172.4？±？8.1？mm Hg收缩压），持续4？周，持续30？min /天，5？day /周。 20？m.min ？1 。训练后，进行了新颖的MLSS和增量测试，以评估动物的有氧适应性。此外，将22周龄的SHR（n？=？12，〜169.8？±？13.8？mm Hg收缩压）分为未锻炼（CG，n？=？4），低强度（LIG， n？=？4）和高强度（HIG，n？=？4）组，其中大鼠以16？m.min ？1 和23？m.min ？1进行训练分别为30？min /天，5？day / week和4？weeks。结果在MLSS上进行的锻炼增强了有氧健身能力，从而导致了一种新的MLSS，在30？m.min ？1 左右被确定。低强度和高强度训练可降低收缩压，只有高强度训练才能改善有氧健身能力（28.1％，p？结论）因此，我们的数据表明，低强度和高强度运动可导致血压降低，有氧健身度增加由SHR中的高强度锻炼提供。

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