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首页> 外文期刊>BMC Plant Biology >Highly syntenic regions in the genomes of soybean, Medicago truncatula , and Arabidopsis thaliana
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Highly syntenic regions in the genomes of soybean, Medicago truncatula , and Arabidopsis thaliana

机译：大豆，紫花苜蓿和拟南芥基因组中的高度同义区域

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Background Recent genome sequencing enables mega-base scale comparisons between related genomes. Comparisons between animals, plants, fungi, and bacteria demonstrate extensive synteny tempered by rearrangements. Within the legume plant family, glimpses of synteny have also been observed. Characterizing syntenic relationships in legumes is important in transferring knowledge from model legumes to crops that are important sources of protein, fixed nitrogen, and health-promoting compounds. Results We have uncovered two large soybean regions exhibiting synteny with M. truncatula and with a network of segmentally duplicated regions in Arabidopsis . In all, syntenic regions comprise over 500 predicted genes spanning 3 Mb. Up to 75% of soybean genes are colinear with M. truncatula , including one region in which 33 of 35 soybean predicted genes with database support are colinear to M. truncatula . In some regions, 60% of soybean genes share colinearity with a network of A. thaliana duplications. One region is especially interesting because this 500 kbp segment of soybean is syntenic to two paralogous regions in M. truncatula on different chromosomes. Phylogenetic analysis of individual genes within these regions demonstrates that one is orthologous to the soybean region, with which it also shows substantially denser synteny and significantly lower levels of synonymous nucleotide substitutions. The other M. truncatula region is inferred to be paralogous, presumably resulting from a duplication event preceding speciation. Conclusion The presence of well-defined M. truncatula segments showing orthologous and paralogous relationships with soybean allows us to explore the evolution of contiguous genomic regions in the context of ancient genome duplication and speciation events.
机译：背景技术最近的基因组测序使相关基因组之间的大碱基规模比较成为可能。动物，植物，真菌和细菌之间的比较表明，通过重排可以调节广泛的协同作用。在豆类植物家族中，也观察到了同调现象。表征豆科植物的同系关系对于将知识从模型豆科植物转移到作物上非常重要，这些作物是蛋白质，固定氮和促进健康的化合物的重要来源。结果我们在拟南芥中发现了两个大大豆区域，与截枝梭菌并存，并有部分重复的区域网络。共有区域包含500多个跨越3 Mb的预测基因。高达75％的大豆基因与M. truncatula共线，包括一个区域，其中有数据库支持的35个大豆预测基因中有33个与M. truncatula共线。在某些地区，60％的大豆基因与拟南芥复制网络共享共线性。一个区域特别有趣，因为大豆的这个500 kbp片段与不同染色体上的截枝分枝杆菌的两个旁系同源。对这些区域内单个基因的系统发生分析表明，一个基因与大豆区域是直系同源的，由此它也显示出实质上更紧密的同位和显着较低的同义核苷酸取代水平。推测其他的截短支原体区域是旁系同源的，大概是由于物种形成之前的重复事件造成的。结论存在明确的，与大豆存在直系同源和旁系亲缘关系的截枝分枝杆菌片段，使我们能够在古代基因组复制和物种形成事件的背景下探索连续基因组区域的演变。

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