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首页> 外文期刊>British Journal of Medicine and Medical Research >A Cross-sectional Study of the Prevalence of Asymptomatic Bacteriuria among HIV-positive and HIV-negative Expectant Mothers in a Tertiary Health Centre in South Eastern Nigeria
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A Cross-sectional Study of the Prevalence of Asymptomatic Bacteriuria among HIV-positive and HIV-negative Expectant Mothers in a Tertiary Health Centre in South Eastern Nigeria

机译：在尼日利亚东南部一家三级医疗中心对HIV阳性和HIV阴性孕妇中无症状细菌尿的患病率进行横断面研究

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Background: Asymptomatic Bacteriuria (ASB) in pregnancy is associated with potential urinary and obstetric complications. The diagnosis and management of ASB in expectant mothers is in keeping with safe motherhood initiative. Aim: To determine the prevalence and pattern of ASB among HIV-positive and HIV-negative pregnant women in Enugu State, South Eastern Nigeria. Methods: This was a comparative analytical study among HIV-positive and HIV-negative pregnant women at the University of Nigeria Teaching Hospital, Enugu State. ‘Clean catch’ urine samples of these women collected and analysed. Statistical analysis was performed using the Chi-square and student’s t tests as appropriate. A P-value of less than 0.05 was considered statistically significant. Results: Among the two hundred and forty HIV-positive women, (23.3%) had significant ASB while (10.4%) of an equal number of HIV-negative women had significant ASB. The difference was statistically significant (p=0.013). A higher proportion of HIV-positive women, (22.5%) with CD4 cell count of ≤ 500/mm3 had significant ASB (p=0.015). Escherichia coli was the commonest isolate in both groups of women. The isolates were generally sensitive to amoxicillin-clavullanic acid, nitrofurantoin and cefuroxime in the two groups. The sensitivity to sulfametoxazle-trimethoprim was low; HIV positive (21.5%), HIV negative (16.0%). Among those treated, none had overt UTI in pregnancy. Conclusion: Screening, treatment and follow up for ASB in pregnancy are necessary especially in HIV positive women with CD4 cell count less than 500/mm3. This should be included during counselling in all antenatal protocols.
机译：背景：妊娠期无症状细菌尿（ASB）与潜在的泌尿和产科并发症有关。孕妇中ASB的诊断和管理符合安全孕产的倡议。目的：确定尼日利亚东南部恩古格州艾滋病毒呈阳性和艾滋病毒呈阴性的孕妇中ASB的流行情况和模式。方法：这是对位于埃努古州尼日利亚大学教学医院的HIV阳性和HIV阴性孕妇的比较分析研究。收集并分析了这些妇女的“干净捕获”尿液样本。使用卡方检验和学生的t检验进行统计分析。小于0.05的P值被认为具有统计学意义。结果：在240例HIV阳性女性中，（23.3％）的ASB显着，而在相等数量的HIV阴性女性中（10.4％）的ASB显着。差异具有统计学意义（p = 0.013）。 CD4细胞计数≤500 / mm 3 的HIV阳性女性比例较高（22.5％），其ASB值较高（p = 0.015）。大肠杆菌是两组女性中最常见的分离株。两组中的分离株通常对阿莫西林-克拉维酸，硝基呋喃妥因和头孢呋辛敏感。对磺胺甲恶唑甲氧苄氨嘧啶的敏感性低。 HIV阳性（21.5％），HIV阴性（16.0％）。在接受治疗的人中，没有人在怀孕期间出现过明显的尿路感染。结论：妊娠期ASB的筛查，治疗和随访是必要的，尤其是对于CD4细胞计数低于500 / mm 3 的HIV阳性女性。在所有产前治疗方案的咨询过程中应包括此内容。

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