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Randomized controlled pilot trial of supportive text messages for patients with depression

机译：抑郁症患者支持性短信的随机对照试验

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Background Depression is projected to be the primary cause of disability worldwide by 2030. In a recent survey, the most commonly cited unmet need among 42.4% of depressed Albertans was the lack of sufficient, accessible, and affordable counselling. Our aim was to test the efficacy of a supportive text messaging mobile health intervention in improving treatment outcomes in depressed patients. Methods We performed a single-rater-blinded randomized trial involving 73 patients with Major Depressive Disorder. Patients in the intervention group ( n =?35) received twice-daily supportive text messages for 3?months while those in the control group ( n =?38) received a single text message every fortnight thanking them for participating in the study. The primary outcome of this study was: “Mean changes in the BDI scores from baseline“. Results After adjusting for baseline BDI scores, a significant difference remained in the 3 month mean BDI scores between the intervention and control groups: (20.8 (SD?=?11.7) vs. 24.9 (SD?=?11.5), F (1, 60)?=?4.83, p =?0.03, ηp2?=?0.07). The mean difference in the BDI scores change was significant with an effect size (Cohen’s d) of 0.67. Furthermore, after adjusting for baseline scores, a significant difference remained in the 3 month mean self-rated VAS scores (EQ-5D-5?L scale) between the intervention and control groups, 65.7 (SD?=?15.3) vs. 57.4 (SD?=?22.9), F (1, 60) =4.16, p =?0.05, ηp2?=?0.065. The mean difference in change mean self-rated VAS scores was also statistically significant with an effect size (Cohen’s d) of 0.51. Conclusions Our findings suggest that supportive text messages are a potentially useful psychological intervention for depression, especially in underserved populations. Further studies are needed to explore the implications of our findings in larger clinical samples. Trial registration ClinicalTrials.gov NCT02327858 . Registered 24 December 2014.
机译：背景技术预计到2030年，抑郁症将成为全球残疾的主要原因。在最近的一项调查中，在42.4％的阿尔伯塔省抑郁症患者中，最常被提及的未满足需求是缺乏足够，容易获得且负担得起的咨询服务。我们的目标是测试支持性短信移动健康干预在改善抑郁症患者治疗效果方面的功效。方法我们对73名重度抑郁症患者进行了单盲盲随机试验。干预组（n = 35）每天两次接受支持文本消息，持续3个月，而对照组（n = 38）则每两周收到一条文本消息，感谢他们的参与。这项研究的主要结果是：“ BDI评分相对于基线的平均变化”。结果调整基线BDI分数后，干预组和对照组的3个月平均BDI分数仍存在显着差异：（20.8（SD？=？11.7）vs. 24.9（SD？=？11.5），F（1， 60）≥4.83，p ＝ 0.03，ηp2≥0.07）。 BDI得分变化的平均差异显着，效应大小（Cohen d）为0.67。此外，在调整了基线分数之后，干预组和对照组之间的3个月平均自我评估的VAS分数（EQ-5D-5？L量表）仍然存在显着差异，分别为65.7（SD？=？15.3）和57.4。 （SD≤22.9），F（1，60）＝ 4.16，p≤0.05，ηp2≤0.065。自我评估的VAS评分变化的平均差异在统计学上也具有统计学意义，效应大小（Cohen d）为0.51。结论我们的发现表明，支持性短信是一种可能对抑郁症有潜在作用的心理干预措施，尤其是在服务不足的人群中。需要进一步的研究来探索我们的发现在更大的临床样本中的含义。试用注册ClinicalTrials.gov NCT02327858。 2014年12月24日注册。

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