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首页> 外文期刊>BMC Psychiatry >Experiences of antipsychotic use in patients with early psychosis: a two-year follow-up study
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Experiences of antipsychotic use in patients with early psychosis: a two-year follow-up study

机译：早期精神病患者使用抗精神病药的经验：为期两年的随访研究

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Background Non-adherence is a major public health problem despite treatment advances. Poor drug adherence in patients with psychosis is associated with more frequent relapse, re-hospitalization, increased consumption of health services and poor outcomes on a variety of measures. Adherence rate in patients with first episode psychosis have been found to vary from 40 to 60%. However, most previous studies have addressed the consequences of non-adherence rather than its potential causes. The purpose of this study was, therefore, to investigate experiential factors which may affect adherence to medication in adults with psychotic disorders, during the 24-month period after the onset of treatment. Methods Twenty first episode patients (7 male, 13 female) were included in our qualitative sub-study from the ongoing TIPS2 (Early Intervention in Psychosis study). Each person participated in semi-structured interviews at 2-year follow-up. All had used antipsychotics, with some still using them. Data were analyzed within an interpretative-phenomenological framework using an established meaning condensation procedure. Results The textual analysis revealed four main themes that affected adherence largely: 1) Positive experiences of admission, 2) Sufficient timely information, 3) Shared decision-making and 4) Changed attitudes to antipsychotics due to their beneficial effects and improved insight into illness. Conclusion Patients reported several factors to have a prominent impact on adherence to their antipsychotics. The patients do not independently choose to jeopardize their medication regime. Health care staff play an important role in maintaining good adherence by being empathetic and supportive in the admission phase, giving tailored information according to patients’ condition and involving patients when making treatment decisions.
机译：背景技术尽管治疗取得了进步，但是不依从仍然是主要的公共卫生问题。精神病患者对药物的依从性差会导致复发频率增加，再次住院，医疗服务的消耗增加以及各种措施的预后不良。发现患有首发精神病的患者的依从率从40％到60％不等。但是，大多数先前的研究都针对不遵守的后果，而不是其潜在原因。因此，本研究的目的是调查在治疗开始后的24个月内，可能影响患有精神病的成年人对药物依从性的经验因素。方法我们从正在进行的TIPS2（精神病早期干预研究）的定性子研究中纳入了20名首发患者（男7例，女13例）。在2年的随访中，每个人都参加了半结构化访谈。所有人都使用过抗精神病药，有些仍在使用。使用建立的意义缩合程序在解释现象学框架内分析数据。结果文本分析揭示了四个主要主题，这些主题在很大程度上影响了依从性：1）积极的入院经历; 2）足够的及时信息; 3）共同的决策制定; 4）由于抗精神病药的有益作用和对疾病的洞察力提高，态度发生了变化。结论患者报告了多种因素对他们的抗精神病药物依从性有显着影响。患者不会独立选择危害其药物治疗方案。医护人员在入院阶段要表现出同情和支持，根据患者的病情提供量身定制的信息，并在制定治疗方案时让患者参与，从而在保持良好依从性方面发挥重要作用。

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