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首页> 外文期刊>BMC Psychiatry >Shared facial emotion processing functional network findings in medication-na?ve major depressive disorder and healthy individuals: detection by sICA
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Shared facial emotion processing functional network findings in medication-na?ve major depressive disorder and healthy individuals: detection by sICA

机译：在未接受药物治疗的重度抑郁症患者和健康个体中共享的面部情绪处理功能网络发现：通过sICA检测

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The fundamental mechanism underlying emotional processing in major depressive disorder (MDD) remains unclear. To better understand the neural correlates of emotional processing in MDD, we investigated the role of multiple functional networks (FNs) during emotional stimuli processing. Thirty-two medication-na?ve subjects with MDD and 36 healthy controls (HCs) underwent an emotional faces fMRI task that included neutral, happy and fearful expressions. Spatial independent component analysis (sICA) and general linear model (GLM) were conducted to examine the main effect of task condition and group, and two-way interactions of group and task conditions. In sICA analysis, MDD patients and HCs together showed significant differences in task-related modulations in five FNs across task conditions. One FN mainly involving the ventral medial prefrontal cortex showed lower activation during fearful relative to happy condition. Two FNs mainly involving the bilateral inferior frontal gyrus and temporal cortex, showed opposing modulation relative to the ventral medial prefrontal cortex FN, i.e., greater activation during fearful relative to happy condition. Two remaining FNs involving the fronto-parietal and occipital cortices, showed reduced activation during both fearful and happy conditions relative to the neutral condition. However, MDD and HCs did not show significant differences in expression-related modulations in any FNs in this sample. SICA revealed differing functional activation patterns than typical GLM-based analyses. The sICA findings demonstrated unique FNs involved in processing happy and fearful facial expressions. Potential differences between MDD and HCs in expression-related FN modulation should be investigated further.
机译：重度抑郁症（MDD）中情绪处理的基本机制仍不清楚。为了更好地理解MDD中情绪处理的神经相关性，我们研究了情绪刺激处理过程中多功能网络（FNs）的作用。接受过MDD和36个健康对照（HCs）训练的32名未接受过药物治疗的受试者接受了包括中性，快乐和恐惧表情在内的情感面部fMRI任务。进行了空间独立成分分析（sICA）和通用线性模型（GLM），以检验任务条件和组的主要影响，以及组和任务条件的双向交互作用。在sICA分析中，MDD患者和HC一起显示了跨任务条件的五个FN中与任务相关的调制的显着差异。相对于快乐状态，一个主要累及腹内侧前额叶皮层的FN在恐惧期间显示出较低的激活。主要涉及双侧下额回和颞皮质的两个FN相对于腹内侧前额皮质FN表现出相反的调制，即在相对于快乐状态的恐惧中更大的激活。与中立状态相比，剩下的两个涉及额顶叶和枕叶皮质的FN表现出在恐惧和快乐状态下激活减少。但是，在此样品中，MDD和HC在任何FN中的表达相关调节上均未显示明显差异。 SICA揭示了与典型的基于GLM的分析不同的功能激活模式。 sICA研究结果表明，独特的FN参与处理快乐和恐惧的面部表情。表达相关的FN调节中MDD和HCs之间的潜在差异应进一步研究。

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