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首页> 外文期刊>BMC Psychiatry >Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT
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Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

机译：通过SPECT / CT评估重度抑郁症的严重程度以表征区域性脑灌注

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Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99?m ethylcysteinate dimer ([99mTc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting. The severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA. [99mTc]ECD rCBF SPECT/CT was performed in 20 healthy controls and 74 unipolar MDD patients before receiving the treatment. The CT attenuation-corrected SPECT images data were automatically registered, analyzed simultaneously by 3D-SSP and eZIS. The mean score of HAMD and HAMA in the MDD patients was 25.49?±?6.00, and 23.12?±?5.83, respectively. There was a positive correlation between two scores. The MDD women had higher HAMD scores than MDD men. The decreased rCBF of MDD patients in frontal lobes (bilateral B11, B47 and right B4, B6, B10, B46), temporal lobe (right B21, B41, B42) and cingulated cortex (bilateral B24, B33), while their increased rCBF in occipital lobe (bilateral B17, B19 and left B18). Additionally, the depression severity was negatively correlated with decreased rCBF in left ventral anterior cingulate cortex B24, and was positively correlated with decreased rCBF in left inferior prefrontal gyrus B47 and increased rCBF in right associative visual cortex B19. The anxiety severity was negatively correlated with decreased rCBF in left subgenual cortex B25. Although the mechanism underlying the correlation is not yet fully understood, our findings indicated that the rCBF SPECT/CT may provide an objective assessment for MDD severity. It might be used monitoring therapeutic efficacy in the management of MDD.
机译：重度抑郁症（MDD）是全世界范围内的常见精神疾病，但是现在缺乏对MDD进行临床有效评估和管理的方法。在这项研究中，我们使用tech 99？m半胱氨酸二聚体（[99mTc] ECD）SPECT / CT来表征MDD患者的局部脑血流（rCBF）状态，并探索非MDD的客观图像评估模型-或在临床环境中微创，方便且准确。三名受过训练的精神科医生根据从HAMD和HAMA获得的评分评估了MDD的严重程度。 [99mTc] ECD rCBF SPECT / CT在接受治疗前在20名健康对照者和74名单相MDD患者中进行。自动校正CT衰减校正的SPECT图像数据，并通过3D-SSP和eZIS同时进行分析。 MDD患者中HAMD和HAMA的平均得分分别为25.49±±6.00和23.12±±5.83。两个分数之间存在正相关。 MDD女性的HAMD得分高于男性。 MDD患者额叶（双侧B11，B47和右B4，B6，B10，B46），颞叶（右B21，B41，B42）和带扣皮层（双侧B24，B33）的rCBF降低，而他们的rCBF升高枕叶（双侧B17，B19和左B18）。此外，抑郁的严重程度与左腹前扣带回皮层B24中的rCBF降低呈负相关，与左下额前回B47中的rCBF降低和右相关性视皮层B19中的rCBF呈正相关。焦虑程度与左下皮质B25的rCBF降低呈负相关。尽管尚未完全理解相关性的潜在机制，但我们的发现表明，rCBF SPECT / CT可能为MDD严重性提供客观评估。它可用于监测治疗MDD的疗效。

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