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首页> 外文期刊>BMC Psychiatry >Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress
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Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress

机译：一系列具有自我报告的创伤后压力症状的个体的病例，与使用闭环同种异体神经技术相关的临床，半球和自主神经变化

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Background The objective of this pilot study was to explore the use of a closed-loop, allostatic, acoustic stimulation neurotechnology for individuals with self-reported symptoms of post-traumatic stress, as a potential means to impact symptomatology, temporal lobe high frequency asymmetry, heart rate variability (HRV), and baroreflex sensitivity (BRS). Methods From a cohort of individuals participating in a naturalistic study to evaluate use of allostatic neurotechnology for diverse clinical conditions, a subset was identified who reported high scores on the Posttraumatic Stress Disorder Checklist (PCL). The intervention entailed a series of sessions wherein brain electrical activity was monitored noninvasively at high spectral resolutions, with software algorithms translating selected brain frequencies into acoustic stimuli (audible tones) that were delivered back to the user in real time, to support auto-calibration of neural oscillations. Participants completed symptom inventories before and after the intervention, and a subset underwent short-term blood pressure recordings for HRV and BRS. Changes in temporal lobe high frequency asymmetry were analyzed from baseline assessment through the first four sessions, and for the last four sessions. Results Nineteen individuals (mean age 47, 11 women) were enrolled, and the majority also reported symptom scores that exceeded inventory thresholds for depression. They undertook a median of 16 sessions over 16.5?days, and 18 completed the number of sessions recommended. After the intervention, 89% of the completers reported clinically significant decreases in post-traumatic stress symptoms, indicated by a change of at least 10 points on the PCL. At a group level, individuals with either rightward ( n =?7) or leftward ( n =?7) dominant baseline asymmetry in temporal lobe high frequency (23–36?Hz) activity demonstrated statistically significant reductions in their asymmetry scores over the course of their first four sessions. For 12 individuals who underwent short-term blood pressure recordings, there were statistically significant increases in HRV in the time domain and BRS (Sequence Up). There were no adverse events. Conclusion Closed-loop, allostatic neurotechnology for auto-calibration of neural oscillations appears promising as an innovative therapeutic strategy for individuals with symptoms of post-traumatic stress. Trials registration ClinicalTrials.gov #NCT02709369 , retrospectively registered on March 4, 2016.
机译：背景技术这项实验性研究的目的是探索一种针对患有创伤后应激障碍的自我报告症状的个体使用闭环，变声，听觉刺激神经技术的方法，以作为一种可能的方法来影响症状，颞叶高频不对称，心率变异性（HRV）和压力反射敏感性（BRS）。方法从一组参加自然主义研究的个体中评估对不同临床状况使用同种异体神经技术的评估，确定了一个在创伤后应激障碍检查表（PCL）上评分较高的亚组。干预需要进行一系列的会议，其中以高频谱分辨率无创地监测大脑的电活动，并通过软件算法将选定的大脑频率转换为声音刺激（可听见的声音），并实时反馈给用户，以支持对脑电活动的自动校准。神经振荡。参与者在干预之前和之后均完成了症状清查，并对一部分患者进行了HRV和BRS的短期血压记录。从基线评估到前四节以及最后四节，分析颞叶高频不对称性的变化。结果招募了19个人（平均年龄47，11位女性），并且大多数人的症状评分也超过了抑郁症的清单阈值。他们在16.5天的时间里平均进行了16次训练，其中18次完成了建议的训练次数。干预后，89％的完成者报告了创伤后应激症状的临床显着减少，PCL改变至少10分表明。在小组水平上，颞叶高频（23–36？Hz）活动中具有右向（n =？7）或向左（n =？7）显性基线不对称的个体在整个过程中显示出其不对称分数的统计学显着降低前四节课中对于接受短期血压记录的12个人，HRV在时域和BRS（Sequence Up）方面有统计学上的显着增加。没有不良事件。结论用于神经震荡自动校准的闭环同构神经技术似乎有望成为具有创伤后应激症状的个体的创新治疗策略。试验注册ClinicalTrials.gov＃NCT02709369，回顾性注册于2016年3月4日。

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