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首页> 外文期刊>Biochemistry research international >Antiatherosclerotic and Cardioprotective Potential ofAcacia senegalSeeds in Diet-Induced Atherosclerosis in Rabbits
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Antiatherosclerotic and Cardioprotective Potential ofAcacia senegalSeeds in Diet-Induced Atherosclerosis in Rabbits

机译：塞内加尔相思种子在饮食诱导的兔动脉粥样硬化中的抗动脉粥样硬化和心脏保护作用

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Acacia senegalL. (Fabaceae) seeds are essential ingredient of “Pachkutta,” a specific Rajasthani traditional food. The present study explored antiatherosclerotic and cardioprotective potential ofAcacia senegalseed extract, if any, in hypercholesterolemic diet-induced atherosclerosis in rabbits. Atherosclerosis in rabbits was induced by feeding normal diet supplemented with oral administration of cholesterol (500 mg/kg body weight/day mixed with coconut oil) for 15 days. Circulating total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglycerides, and VLDL-cholesterol (VLDL-C) levels; atherogenic index (AI); cardiac lipid peroxidation (LPO); planimetric studies of aortal wall; and histopathological studies of heart, aorta, kidney, and liver were performed. Apart from reduced atherosclerotic plaques in aorta (6.34±0.72) and increased lumen volume (51.65±3.66), administration with ethanolic extract ofAcacia senegalseeds (500 mg/kg/day, p.o.) for 45 days to atherosclerotic rabbits significantly lowered serum TC, LDL-C, triglyceride, and VLDL-C levels and atherogenic index as compared to control. Atherogenic diet-induced cardiac LPO and histopathological abnormalities in aorta wall, heart, kidney, and liver were reverted to normalcy byAcacia senegalseed extract administration. The findings of the present study reveal thatAcacia senegalseed extract ameliorated diet-induced atherosclerosis and could be considered as lead in the development of novel therapeutics.
机译：塞内加尔相思。 （豆科）种子是拉贾斯坦邦的传统食品“ Pachkutta”的基本成分。本研究探讨了金合欢塞内加尔种子提取物在高胆固醇饮食引起的兔动脉粥样硬化中的抗动脉粥样硬化和心脏保护作用。饲喂补充胆固醇的正常饮食（500μg/ kg体重/天，每天混合椰子油）15天，可诱发兔的动脉粥样硬化。循环总胆固醇（TC），HDL-胆固醇（HDL-C），LDL-胆固醇（LDL-C），甘油三酸酯和VLDL-胆固醇（VLDL-C）水平;动脉粥样硬化指数（AI）;心脏脂质过氧化（LPO）;主动脉壁的平面研究;并进行了心脏，主动脉，肾脏和肝脏的组织病理学研究。除了主动脉粥样斑块减少（6.34±0.72）和管腔容积增加（51.65±3.66）外，还用塞内加尔刺槐种子乙醇提取物（500μmg/ kg /天，口服）给药45天，使动脉粥样硬化兔的血清TC，LDL明显降低-C，甘油三酸酯和VLDL-C水平以及动脉粥样硬化指数与对照相比。通过塞内加尔籽相思提取物的使用，使致动脉粥样化饮食引起的心脏LPO和主动脉壁，心脏，肾脏和肝脏的组织病理学异常恢复正常。本研究的发现表明，相思树塞内加尔种子提取物改善了饮食诱导的动脉粥样硬化，可以被认为是新型疗法发展的先导。

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