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首页> 外文期刊>British Journal of Medicine and Medical Research >Evaluation of the Crimean-Congo Hemorrhagic Fever Cases Followed and Treated in Our Clinic between 2009-2013
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Evaluation of the Crimean-Congo Hemorrhagic Fever Cases Followed and Treated in Our Clinic between 2009-2013

机译：2009-2013年间我院门诊和治疗的克里米亚-刚果出血热病例评估

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Objectives: The Crimean-Congo hemorrhagic fever virus (CCHFV) belongs to the family Bunyaviridae, genus Nairovirus, and causes severe disease in man; the reported case-fatality rate is 3%–30%. The aim of this study was to determine the epidemiological and clinical characteristics of the CCHF cases in our clinic between 2009-2013. Materials and Methods: Thirty-three patients with the diagnosis of CCHF were followed up in Kayseri Training and Research Hospital between January 2009 and September 2013. Demographic, geographic, climatic, and clinical and laboratory characteristics of all patients were investigated. All of the cases were confirmed by CCHF immunoglobulin M (IgM) and/or PCR RNA positivity. Results: According to our reports 33 CCHF cases were followed in our clinic. Of the CCHF cases, 63.6% were male. Thirty patients (90.9%) were from rural regions. Seventeen patients (51, 5%) were farmers. The median age was 46.7 years (range18-71 years). On admission, 97% of patients experienced high fever, 100% had weakness, 93.9% had headache. The disease was more usual in May, June, July. Of the CCHF cases, 69.7% had a history of tick bite. On admission, all of the patients had thrombocytopenia, 87.9% had leucopenia, 27.3% had anemia, and 87.9% had elevated AST and ALT. Oral ribavirin treatment was used in 33.3% of the CCHF cases. The case-fatality rate was 12.1% (4/33 patients). Conclusions: CCHF remains a seasonal problem in the Mid-Eastern Anatolia region of Turkey. The mortality rate in our patients was higher than reported in other studies in our country (12% vs 5%). CCHF should be accompanied with supportive care, especially including early platelet replacement.
机译：目的：克里米亚-刚果出血热病毒（CCHFV）属于奈洛病毒属布尼亚病毒科，可引起人类严重疾病。报告的病死率为3％–30％。这项研究的目的是确定2009-2013年间我院CCHF病例的流行病学和临床特征。材料与方法：2009年1月至2013年9月在开塞利培训研究医院对33例诊断为CCHF的患者进行了随访。调查了所有患者的人口统计学，地理，气候以及临床和实验室特征。所有病例均通过CCHF免疫球蛋白M（IgM）和/或PCR RNA阳性证实。结果：根据我们的报告，我们的诊所共随访了33例CCHF病例。在CCHF病例中，男性占63.6％。 30名患者（90.9％）来自农村地区。农场主有17名患者（51，5％）。中位年龄为46.7岁（范围18-71岁）。入院时97％的患者发高烧，100％的患者无力，93.9％的患者头痛。这种病在五月，六月，七月更为常见。在CCHF病例中，有69.7％的人有of虫叮咬史。入院时，所有患者均患有血小板减少症，白血球减少症为87.9％，贫血为27.3％，AST和ALT升高为87.9％。 33.3％的CCHF病例采用口服利巴韦林治疗。病死率为12.1％（4/33例）。结论：CCHF在土耳其中东部安纳托利亚地区仍然是一个季节性问题。我们患者的死亡率高于我国其他研究报告的死亡率（12％比5％）。 CCHF应伴以支持性护理，尤其是早期血小板替代。

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