• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brazilian Journal of Oral Sciences >Parental age is related to the occurrence of cleft lip and palate in Brazilian populations
【24h】

Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

机译：父母年龄与巴西人群唇left裂的发生有关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age 35, 36-39, and ≥40 years; paternal age 39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father’s aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father’s age and the child’s gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father’s age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts.
机译：目的：评估新生儿非综合征性唇裂伴或不伴left裂的环境危险因素（尤其是父亲和母亲的年龄）与性别和口腔裂隙类型的关系（NSCL / P）。方法：本研究纳入了来自巴西两个服务部门的1,346例NSCL / P儿童，以治疗颅面畸形。父母的年龄分为以下几类：产妇年龄<35、36-39和≥40岁;父亲年龄<39岁且≥40岁。使用卡方检验和多项式逻辑回归分析对数据进行分析。估计的优势比为95％置信区间。结果：本研究纳入的1,346名儿童中，CLP是患病率最高的NSCL / P类型，其次是CL和CP。与女性相比，男性中NSCL / P的发生率更高（55.8％对44.2％）。 CLP在男性中更为常见，而CL和CP在女性中更为普遍（p = 0.000）。未观察到产妇年龄与c裂之间的关联（p = 0.747）。但是，有证据表明，年龄≥40岁的父亲与NSCL / P有关联（p = 0.031）。当分别对CP患者进行分析时，未发现父亲的年龄与孩子的性别之间存在关联（p = 0.728），即CP的患者中女性占主导地位，而与父亲的年龄无关。结论：这项研究表明，非综合征性唇裂和/或pa裂的分布与性别存在差异，年龄≥40岁的父亲患口腔裂的风险可能增加。需要对涉及不同人群的进一步研究，以更好地了解母亲和父亲年龄是口腔裂发生的危险因素的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号