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首页> 外文期刊>Brazilian Journal of Pharmaceutical Sciences >Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction
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Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

机译：桔梗桔梗汤的抗糖尿病作用

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The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.
机译：这项研究的目的是确定使用坎波莫尼亚xanthocarpa Berg叶片汤剂对正常和链脲佐菌素诱导的糖尿病大鼠进行3周治疗的效果。 （20 g / L）的生理，生化和组织学参数。在治疗前一周腹膜内注射链脲佐菌素（STZ，柠檬酸盐缓冲液中的70 mg / kg，pH 4.5）以诱导实验性糖尿病。 STZ引起典型的糖尿病症状：胰腺，肝脏和肾脏的多发性增生，多尿，多食，高血糖，高甘油三酸酯血症和组织病理改变。用该汤剂治疗糖尿病大鼠可降低血糖水平，抑制肝糖原损失，并预防胰腺和肾脏的潜在组织病理学改变。在用汤治疗的对照大鼠和仅保持水的对照大鼠之间没有发现差异。综上所述，这些结果表明黄果皮叶汤（20g / L）可能对糖尿病的治疗有用，但是还需要进一步的药理和毒理学研究。

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