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首页> 外文期刊>Cancer and Clinical Oncology >A Single Centre Retrospective Analysis of Toxicity, Prognostication and Oncological Outcomes in Clinical Stage One Seminoma Treated with Carboplatin
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A Single Centre Retrospective Analysis of Toxicity, Prognostication and Oncological Outcomes in Clinical Stage One Seminoma Treated with Carboplatin

机译：卡铂治疗临床第一期精原细胞瘤的毒性，预后和肿瘤学结果的单中心回顾性分析

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Aim: The aim of this retrospective study was to investigate the clinical role and side effect profile of adjuvant carboplatin in patients with clinical stage one seminoma. Methods: Twenty four patients with stage one seminoma who were treated with carboplatin were assessed retrospectively. Result: 54% (13/24) of patients experienced no acute toxicities with carboplatin.17%(8/24) had grade 1 myelosupression, 8% (2/24)had fatigue and 4%(1/24) had epididymo-orchitis.In terms of long-term toxicities due to carboplatin; 67% (15/24) were well at follow up,13% (3/24) had gastrointestinal toxicity,8% (2/24) had pulmonary changes ,4% (1/24)had grade two fatigue,4%(1/24) had a cardiac event and 4%(1/24) had erectile dysfunction.17% (4/24)had high risk histologic features with a tumour size greater than 4 cm and rete testis involvement.4% (1/24) patient had recurrent disease. 4% (1/24) patient had a second malignancy. All patients were alive at follow up. Conclusions: Our findings suggest that carboplatin is a safe and well tolerated alternative to Active Surveillance in a selected group of patients.
机译：目的：这项回顾性研究的目的是研究辅助卡铂在临床一期精原细胞瘤患者中的临床作用和副作用。方法：回顾性分析接受卡铂治疗的24例一期精原细胞瘤患者。结果：54％（13/24）的患者未出现卡铂急性毒性。17％（8/24）的患者为1级骨髓抑制，8％（2/24）的患者为疲劳，4％（1/24）的患者为附睾。睾丸炎。关于卡铂引起的长期毒性; 67％（15/24）有良好的随访表现，13％（3/24）有胃肠道毒性，8％（2/24）有肺部改变，4％（1/24）有二级疲劳，4％（ 1/24）有心脏事件，4％（1/24）有勃起功能障碍。17％（4/24）具有高风险组织学特征，肿瘤大小大于4 cm并累及睾丸网。4％（1 / 24）患者患有复发性疾病。 4％（1/24）患者患有第二次恶性肿瘤。所有患者在随访中均存活。结论：我们的研究结果表明，在部分患者中，卡铂是主动监测的安全且耐受良好的替代方法。

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