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首页> 外文期刊>Canadian Journal of Emergency Medicine >Prevalence of methicillin-resistant Staphylococcus aureus in skin and soft tissue infections in patients presenting to Canadian emergency departments
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Prevalence of methicillin-resistant Staphylococcus aureus in skin and soft tissue infections in patients presenting to Canadian emergency departments

机译：向加拿大急诊科就诊的患者的皮肤和软组织感染中耐甲氧西林金黄色葡萄球菌的患病率

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Background:Community-associated methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly common cause of skin and soft tissue infection (SSTI) worldwide. The prevalence of MRSA in SSTIs across Canada has not been well described. Studies in the United States have shown significant geographic variability in the prevalence of MRSA. This study characterizes the geographic prevalence and microbiology of MRSA in patients presenting to Canadian emergency departments with SSTIs.Methods:Using a prospective, observational design, we enrolled patients with acute purulent SSTIs presenting to 17 hospital emergency departments and 2 community health centres (spanning 6 Canadian provinces) between July 1, 2008, and April 30, 2009. Eligible patients were those whose wound cultures grew S. aureus. MRSA isolates were characterized by antimicrobial susceptibility testing and pulsed-field gel electrophoresis. All patients were subjected to a structured chart audit, and patients whose wound swabs grew MRSA were contacted by telephone to gather detailed information regarding risk factors for MRSA infection, history of illness, and outcomes.Results:Of the 1,353 S. aureus–positive encounters recorded, 431 (32%) grew MRSA and 922 (68%) wounds grew methicillin-susceptible S. aureus. We observed significant variation in both the prevalence of MRSA (11–100%) and the proportion of community-associated strains of MRSA (0– 100%) across our study sites, with a significantly higher prevalence of MRSA in western Canada.Interpretation:MRSA continues to emerge across Canada, and the prevalence of MRSA in SSTIs across Canada is variable and higher than previously expected.
机译：背景：与社区相关的耐甲氧西林的金黄色葡萄球菌（MRSA）是全世界皮肤和软组织感染（SSTI）越来越常见的病因。尚未对加拿大SSTI中MRSA的患病率进行很好的描述。美国的研究表明，MRSA的患病率存在​​明显的地域差异。方法：采用前瞻性，观察性设计，我们对17个医院急诊科和2个社区卫生中心的急性化脓性SSTI患者进行了前瞻性，观察性设计。加拿大各省）在2008年7月1日至2009年4月30日之间。符合条件的患者是那些伤口培养物出现金黄色葡萄球菌的患者。 MRSA分离物通过抗菌药敏试验和脉冲场凝胶电泳进行了表征。所有患者均经过结构化图表审核，并通过电话联系伤口拭子生长为MRSA的患者，以收集有关MRSA感染的危险因素，疾病史和结局的详细信息。结果：在1,353例金黄色葡萄球菌阳性病例中记录表明，有431（32％）的患者生长了MRSA，而922（68％）的伤口生长了对甲氧西林敏感的金黄色葡萄球菌。在我们的研究地点，我们观察到MRSA的流行率（11–100％）和社区相关MRSA菌株的比例（0–100％）均存在显着差异，在加拿大西部，MRSA的患病率明显更高。 MRSA在加拿大各地不断涌现，加拿大各地SSTI中MRSA的流行程度参差不齐，高于先前的预期。

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