...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer and Clinical Oncology >Outcome of Multimodality Therapy for Elderly Colorectal Cancer Patients
【24h】

Outcome of Multimodality Therapy for Elderly Colorectal Cancer Patients

机译：老年大肠癌患者多模式治疗的结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to analyze patterns of multimodality therapy in elderly patients with advanced colorectal cancer. We enrolled 272 patients with colorectal cancer. All patients received chemotherapy and some patients received secondary cytoreductive surgery and/or radiofrequency ablation. We compared differences between elderly patients (age >=75 years) and non-elderly patients (age <75 years), especially in relation to multimodality therapy. There were no significant differences in cancer-specific survival between elderly ( n = 37) and non-elderly patients ( n = 235).Twenty-seven percent of elderly and 35% of non-elderly patients received multimodality therapy, which resulted in prolonged survival. Although the main chemotherapy regimen was the same in both groups who received multimodality therapy, elderly patients who received chemotherapy alone seemed to be under-treated. For elderly patients, prognostic factors were host-related, such as comorbidities, whereas for non-elderly patients prognostic factors were tumor-related. Comorbidities and modified Glasgow Prognostic Score may be prognostic indicators in elderly patients receiving multimodality therapy. In conclusion, chronological age alone should not contraindicate multimodality therapy of colorectal cancer in elderly patients. Appropriate selection criteria for multimodality therapy in elderly patients should include not only tumor characteristics, but also host- and treatment-related factors.
机译：本研究的目的是分析老年晚期大肠癌患者的多模式治疗模式。我们招募了272例大肠癌患者。所有患者均接受化学疗法，部分患者接受二次细胞减灭术和/或射频消融。我们比较了老年患者（年龄> = 75岁）和非老年患者（年龄<75岁）之间的差异，尤其是在多模式疗法方面。老年人（n = 37）和非老年人（n = 235）之间的癌症特异性生存率无显着差异.27％的老年人和35％的非老年人患者接受了多模式治疗。延长生存期。尽管两组接受多模式治疗的主要化疗方案相同，但仅接受化疗的老年患者似乎治疗不足。对于老年患者，预后因素与宿主相关，例如合并症，而对于非老年患者，预后因素与肿瘤相关。合并症和格拉斯哥预后评分的改变可能是接受多模式治疗的老年患者的预后指标。总而言之，仅按年龄排序不应成为老年患者结直肠癌多式联运疗法的禁忌证。对老年患者的综合治疗合适的选择标准应该不仅包括肿瘤的特点，也主机和治疗相关的因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号