• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Emergency Medicine >A randomized, controlled trial of oral versus intravenous fluids for lowering blood glucose in emergency department patients with hyperglycemia
【24h】

A randomized, controlled trial of oral versus intravenous fluids for lowering blood glucose in emergency department patients with hyperglycemia

机译：急诊科高血糖患者口服和静脉输液降低血糖的随机对照试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives:Blood glucose can be lowered via insulin and/or fluid administration. Insulin, although efficacious, can cause hypoglycemia and hypokalemia. Fluids do not cause hypoglycemia or hypokalemia, but the most effective route of fluid administration has not been well described. This study compared the efficacy and safety of oral versus intravenous fluids for reducing blood glucose in patients with hyperglycemia.Methods:We conducted a prospective, nonblinded, randomized, controlled trial. Inclusion criteria were blood glucose > 13.9 mmol/L, age > 18 years, and ability to tolerate oral fluids. Subjects were excluded for critical illness, contraindication to fluids, and/or hyperglycemia therapy prior to enrolment. Subjects were randomized to receive oral bottled water or intravenous normal saline (maximum 2 L) over 2 hours. The primary outcome of interest was a change in blood glucose at 2 hours across treatment arms.Results:The 48 subjects were randomized. Baseline blood glucose levels and total amount of fluid received were similar between the two groups. The mean decrease in blood glucose at 2 hours was similar for both treatment arms: a mean decrease of 3.4 mmol/L (20.2 mmol/L to 16.8 mmol/L) in the oral fluid group versus a mean decrease of 4.0 mmol/L (19.7 mmol/L to 15.7 mmol/L) in the intravenous fluid group. The mean difference between groups was ?0.6 mmol/L (95% confidence interval ?2.3–1.2; p = 0.51). No adverse events were observed in either group.Conclusion:In this unblinded randomized trial, oral and intravenous fluids were equally efficacious in lowering blood glucose levels in stable hyperglycemic patients and no adverse events were noted. Physicians should be mindful that, although similar, the reduction in blood glucose was modest in both groups.
机译：目的：可以通过胰岛素和/或输液来降低血糖。胰岛素虽然有效，但会引起低血糖和低钾血症。输液不会引起低血糖或低钾血症，但是对输液的最有效途径尚未有很好的描述。这项研究比较了口服和静脉输液降低高血糖患者血糖的功效和安全性。方法：我们进行了一项前瞻性，非盲，随机，对照试验。入选标准为血糖> 13.9 mmol / L，年龄> 18岁，以及耐受口服液的能力。入选前，因严重疾病，禁忌液体和/或高血糖治疗而排除受试者。在2小时内将受试者随机接受口服瓶装水或静脉内生理盐水（最大2 L）。感兴趣的主要结果是各治疗组在2小时时血糖的变化。结果：将48名受试者随机分组。两组之间的基线血糖水平和接受的液体总量相似。两个治疗组在2小时时的平均血糖降低相似：口服液组平均降低3.4 mmol / L（从20.2 mmol / L降低到16.8 mmol / L），而平均降低4.0 mmol / L（静脉输液组为19.7 mmol / L至15.7 mmol / L）。两组之间的平均差异为？0.6 mmol / L（95％置信区间为？2.3–1.2; p = 0.51）。两组均未观察到不良事件。结论：在这项无盲的随机试验中，口服和静脉输液对稳定高血糖患者的血糖水平具有同等效力，并且未发现不良事件。医师应注意，尽管相似，但两组血糖均降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号