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首页> 外文期刊>Cancer and Clinical Oncology >Preoperative Staging in Women with Known Breast Cancer: Comparison between Digital Breast Tomosynthesis (DBT) and Magnetic Resonance Imaging (MRI)
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Preoperative Staging in Women with Known Breast Cancer: Comparison between Digital Breast Tomosynthesis (DBT) and Magnetic Resonance Imaging (MRI)

机译：已知乳腺癌女性的术前分期：数字乳腺断层合成（DBT）和磁共振成像（MRI）之间的比较

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Objectives To prospectively evaluate the accuracy in tumor extent and size assessment of Digital Breast Tomosynthesis (DBT) and Magnetic Resonance Imaging (MRI) in women with known breast cancer, with pathological size as the gold standard. Methods From May 2014 to April 2016, 50 patients with known breast cancer were enrolled in our prospective study. All patients underwent MRI on a 3T magnet and DBT projections. Two radiologists, with 15 and 7 years of experience in breast imaging respectively, evaluated in consensus each imaging set unaware of the final histological examination. MR and DBT sensitivity, PPV and accuracy were calculated, using histology as the gold standard. McNemar test was used to compare MR and DBT sensitivity. Correlation and regression analyses were used to evaluate MRI vs Histology, DBT vs Histology and MRI vs DBT lesions tumor size agreement to histological results. Results On histological examination 70 lesions were detected. MRI showed 100% sensitivity, 96% PPV and 96% accuracy; DBT sensitivity was 81%, PPV 92% and accuracy 77%. McNemar test p-value was 0.0003. Lesions size Pearson correlation coefficient was 0.97 for MRI vs Histology, 0.92 for DBT vs Histology, (p-value<0.0001). MRI vs DBT regression coefficient was 0.83. Conclusions MRI confirmed to be the most accurate imaging technique in preoperative staging of breast cancer. However, DBT showed very good accuracy, sensitivity and tumor size assessment and could be a valid tool for preoperative staging when MRI is contraindicated.
机译：目的前瞻性评估已知乳腺癌女性的肿瘤大小和数字乳腺断层合成（DBT）和磁共振成像（MRI）的准确性，以病理大小为金标准。方法从2014年5月至2016年4月，对50例已知乳腺癌患者进行了前瞻性研究。所有患者均在3T磁体和DBT投影上进行MRI。两名分别在乳腺影像学方面有15年和7年经验的放射线医师对每个影像学组没有达成最终组织学检查的共识进行了评估。以组织学为金标准，计算了MR和DBT的敏感性，PPV和准确性。 McNemar测试用于比较MR和DBT敏感性。相关性和回归分析用于评估MRI与组织学，DBT与组织学以及MRI与DBT病变的肿瘤大小与组织学结果的一致性。结果在组织学检查中发现了70个病变。 MRI显示100％的敏感性，96％的PPV和96％的准确性; DBT灵敏度为81％，PPV为92％，准确性为77％。 McNemar检验的p值为0.0003。 MRI与组织学的病变大小皮尔逊相关系数为0.97，DBT与组织学的病变皮尔逊相关系数为0.92（p值<0.0001）。 MRI vs DBT回归系数为0.83。结论MRI被证实是乳腺癌术前分期中最准确的影像学技术。然而，DBT表现出非常好的准确性，敏感性和肿瘤大小评估，并且当MRI禁忌时可以作为术前分期的有效工具。

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