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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >SERUM SIALIC ACID (TOTAL SIALIC ACID AND LIPID ASSOCIATED SIALIC ACID), ?-CAROTENE AND SUPER OXIDE DISMUTASE (SOD) LEVELS IN IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS
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SERUM SIALIC ACID (TOTAL SIALIC ACID AND LIPID ASSOCIATED SIALIC ACID), ?-CAROTENE AND SUPER OXIDE DISMUTASE (SOD) LEVELS IN IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS

机译：患有膝骨骨关节炎的伊拉克患者的血清唾液酸（唾液酸和脂质相关的唾液酸总和），β-胡萝卜素和超氧化物歧化酶（SOD）水平

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Osteoarthritis (OA) is a degenerative joint disease, occurring primarily in older persons, characterized by erosion of the articular cartilage, hypertrophy of bone at the margins (i.e., osteophytes), subchondral sclerosis, and a range of biochemical and morphological alterations of the synovial membrane and joint capsule. In osteoarthritis free radicals may act as triggering factor for degenerative changes seen in cartilage. Oxidative stress leads to increased risk for osteoarthritis but the precise mechanism remains unclear. Sialic acid concentration varies physiologically with age, but its level may also be influenced by such condition as inflammation. The aim of this study was to investigate the changes in the serum sialic acid levels (TSA and LSA), β-Carotene and super oxide dismutase (SOD) in patients with knee osteoarthritis. In this study 96 subjects divided into four groups, 33 patients with obese Knee OA and 25 patients non obese Knee OA, their age range (32-78). The other 38 subjects age and sex matched healthy subjects were studied as controls include 23 obese and 15 non obese. This study was conducted in AL-Kadhemiya Teaching Hospital during the period from October 2011 to April 2012. Serum total sialic acid level, lipid sialic acid, serum β-Carotene and serum SOD were determined. A significant increase in serum sialic acid (TSA & LSA) levels were observed, while there were a significant decrease in serum β-Carotene and SOD levels in patients with knee osteoarthritis when compared to healthy controls. The results of our study suggest higher oxygen free radical production, evidenced by decreased SOD and β- Carotene levels support to the oxidative stress in knee osteoarthritis. The increase of serum TSA and LSA levels is associated positively with the presence of inflammation and could be suggested as one of the many markers for Knee osteoarthritis.
机译：骨关节炎（OA）是一种退行性关节疾病，主要发生于老年人，其特征是关节软骨糜烂，边缘的骨肥大（即骨赘），软骨下硬化以及滑膜的一系列生化和形态学改变膜和关节囊。在骨关节炎中，自由基可能是软骨退行性变化的触发因素。氧化应激导致骨关节炎的风险增加，但确切机制尚不清楚。唾液酸浓度在生理上随年龄而变化，但是其水平也可能受到诸如炎症之类的状况的影响。这项研究的目的是调查膝骨关节炎患者血清唾液酸水平（TSA和LSA），β-胡萝卜素和超氧化物歧化酶（SOD）的变化。在这项研究中，将96位受试者分为四组，即33岁的肥胖膝OA患者和25名非肥胖的膝OA患者，其年龄范围为（32-78）岁。研究了其他38位年龄和性别相匹配的健康受试者，其中包括23名肥胖者和15名非肥胖者。该研究于2011年10月至2012年4月在AL-Kadhemiya教学医院进行。测定了血清总唾液酸水平，脂质唾液酸，血清β-胡萝卜素和血清SOD。与健康对照组相比，膝骨关节炎患者的血清唾液酸（TSA和LSA）水平显着增加，而血清β-胡萝卜素和SOD水平则显着下降。我们的研究结果表明，较高的氧自由基产生，这可通过降低SOD和β-胡萝卜素水平来支持膝盖骨关节炎的氧化应激。血清TSA和LSA水平的升高与炎症的存在呈正相关，可以被认为是膝骨关节炎的许多标志之一。

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