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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >ANTIBACTERIAL AND TOXICOLOGICAL EFFECTS OF METHANOLIC LEAF EXTRACT OF PYRENACANTHA STAUDTII (ENGL.)
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ANTIBACTERIAL AND TOXICOLOGICAL EFFECTS OF METHANOLIC LEAF EXTRACT OF PYRENACANTHA STAUDTII (ENGL.)

机译：火棘叶甲醇叶提取物的抗菌和毒理作用

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摘要

Despite the widespread use of Pyrenacantha staudtii Engl. In the traditional medicine of Nigeria, there is scanty of information on its efficacy and toxicity. The aim of this study was to evaluate the antibacterial activity against the growth of some pathogenic microorganisms and toxicological effects of methanolic extract of the plants in male Wistar albino rats. Phytochemical screening indicated that the extract is rich in alkaloid, tannin, saponins, while anthraquinones, phlobatannins and cardiac glycosides were absent. The histological and heamatological investigations on liver, duodenum and blood samples of the rats that were administered with the extract (acute doses of 30mg/ml and 25mg/ml) showed mild toxicities. However, the control experiment that was given normal saline presented no toxicities on the liver and duodenum cells. The extracts inhibited the growth of Bacillus cereus, Escherichia. coli and Staphylococcus aureus while Shigella dysentriae and Salmonella typhi were resistant to the extract at both concentrations. This is an indication that the extracts may not be completely safe in male rats when continuously administered for 14 days.
机译：尽管Pyrenacantha staudtii Engl被广泛使用。在尼日利亚的传统医学中，关于其功效和毒性的信息很少。这项研究的目的是评估对雄性Wistar白化病大鼠某些病原微生物生长的抗菌活性和植物甲醇提取物的毒理作用。植物化学筛选表明，提取物富含生物碱，单宁，皂苷，而蒽醌，间巴单宁和强心苷不存在。用提取物（急性剂量分别为30mg / ml和25mg / ml）对大鼠肝脏，十二指肠和血液样本进行的组织学和血液学研究显示出轻度的毒性。但是，给予生理盐水的对照实验对肝和十二指肠细胞没有毒性。提取物抑制了蜡样芽胞杆菌，大肠杆菌的生长。大肠杆菌和金黄色葡萄球菌而痢疾志贺氏菌和伤寒沙门氏菌在两种浓度下均对提取物有抗性。这表明，连续服用14天后，提取物在雄性大鼠中可能并不完全安全。

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