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首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >PHYTOCHEMICAL AND BIOLOGICAL EVALUATION OF POLYGONUM AMPLEXICAULE RHIZOME EXTRACT
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PHYTOCHEMICAL AND BIOLOGICAL EVALUATION OF POLYGONUM AMPLEXICAULE RHIZOME EXTRACT

机译：广角根茎提取物的理化和生物评价

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摘要

Medicinal plants have long been recognized for their applications in pharmaceutical, cosmetic, agriculture and food industry. The medicinal plants of genus Polygonum have far been used for a variety of purposes including the treatment of infectious diseases, inflammatory conditions, gastrointestinal disorders and cancer. Polygonum amplexicaule has folk medicinal use in Pakistan for such diseases. Since, the discovery of therapeutic agents depends on the knowledge of chemical constituents of the plant hence the present study was designed to evaluate the phytochemicals present in this specie's rhizome with respect to their importance in the field of phytomedicines. Different phytochemicals were analyzed qualitatively by using various assays. Antitumor and brine shrimp cytoxicity assay were performed along with tyrosinase inhibition assay to check the suitability of the extract for cosmetics. The qualitative analysis of phytochemicals reveals the presence of various secondary metabolites that includes alkaloids, steroids, cardiac glycosides, saponins, fixed oils and fats, phenolic compounds including flavonoids, saponins, tannins and terpenoids, gums and mucilages and anthraquinones, while phytosterols and phlabatannins have not been detected. The rhizome extract has shown significant cytotoxic and antitumor activities with 13.57μg/mL IC 50 towards brine shrimp assay. The tyrosinase inhibition assay validates its suitability for cosmetics with 64.6% tyrosinase inhibition at 10μg/ml treatment. The phytochemicals evaluated in the rhizome extract of P. amplexicaule and its biological activities validates its folkloric use and prospects its future use towards isolation of therapeutic agents.
机译：药用植物因其在制药，化妆品，农业和食品工业中的应用而久负盛名。 Poly属的药用植物已广泛用于多种目的，包括治疗传染病，炎性疾病，胃肠道疾病和癌症。何首乌在巴基斯坦民间用于此类疾病。由于治疗剂的发现取决于植物化学成分的知识，因此，本研究旨在评估它们在植物药领域中的重要性，从而评估该物种的根茎中存在的植物化学物质。通过使用各种测定方法定性分析了不同的植物化学物质。进行抗肿瘤和盐水虾细胞毒性试验以及酪氨酸酶抑制试验，以检查提取物是否适用于化妆品。植物化学物质的定性分析显示存在各种次生代谢产物，包括生物碱，类固醇，强心苷，皂角苷，固定油和脂肪，酚类化合物（包括类黄酮，皂苷，丹宁和萜类化合物，树胶和粘液和蒽醌），而植物甾烷醇具有未检测到。根茎提取物显示出显着的细胞毒性和抗肿瘤活性，其对虾的含量为13.57μg/ mL IC 50。酪氨酸酶抑制试验证实了其对化妆品的适用性，在10μg/ ml的处理量下酪氨酸酶抑制率为64.6％。在山茱。根状茎提取物中评估的植物化学物质及其生物学活性证实了其民间用途，并展望了其未来在分离治疗剂方面的用途。

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