The objective of our study was to evaluate the accuracy of body mass index (BMI) in detecting an elevated alanine transaminase (ALT) level in the college students population. The cross-sectional survey was conducted from 2005 to 2008 based on the health checkup data. A total of 7875 college freshmen were examined. Logistic regression was used to quantify the contribution of BMI to an elevated ALT ( 40 U/L) level. The Receiver Operating Characteristic (ROC) curve was used to calculate the BMI cut-off points for the risk of elevated ALT. BMI was a significant predictor of elevated ALT in both male (OR=1.30, 95%CI:1.24–1.36) and female (OR=1.21, 95%CI:1.60–1.27). The risk of elevated ALT was 38.79 (95%CI:22.46–67.01) fold higher with obesity in male and 21.96 (95%CI:8.24–58.51) fold in female. According to the data of the ROC curve, the BMI cut-off points for predicting the risk of elevated ALT were 24.1 kg/m 2 in male and 21.7 kg/m 2 in female. BMI is a good predictor of elevated ALT serum activity in the college students population. To identify college students population at high risk of elevated ALT in Taiwan, cut-off points little higher than currently recommended overweight for BMI is needed in male students while lower than overweight for BMI is suggested in female.
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机译：我们研究的目的是评估体重指数（BMI）在检测大学生人群中丙氨酸转氨酶（ALT）水平升高的准确性。横断面调查是根据健康检查数据于2005年至2008年进行的。共检查了7875名大学新生。 Logistic回归用于量化BMI对ALT（40 U / L）升高的贡献。受试者工作特征（ROC）曲线用于计算ALT升高风险的BMI临界点。体重指数是男性（OR = 1.30，95％CI：1.24-1.36）和女性（OR = 1.21，95％CI：1.60-1.27）中ALT升高的重要预测指标。男性肥胖引起的ALT升高风险高38.79倍（95％CI：22.46–67.01），女性肥胖风险高21.96倍（95％CI：8.24–58.51）。根据ROC曲线的数据，预测ALT升高风险的BMI临界点是男性为24.1 kg / m 2，女性为21.7 kg / m 2。 BMI是大学生人群ALT血清活性升高的良好预测指标。为了确定台湾有高ALT升高高风险的大学生群体，男性学生的BMI临界点应略高于目前建议的超重水平，而女性则建议低于BMI的超重临界值。
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