...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Pure and Applied Sciences >IMMUNOMODULATORY AND AMELIORATIVE ROLE OF NIGELLA SATIVA OIL ON SCHISTOSOMA MANSONI INFECTED MICE
【24h】

IMMUNOMODULATORY AND AMELIORATIVE ROLE OF NIGELLA SATIVA OIL ON SCHISTOSOMA MANSONI INFECTED MICE

机译：苜蓿油对曼氏血吸虫感染小鼠的免疫调节和改善作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Schistosomiasis is one of the world’s most prevalent parasitic diseases and cause of morbidity and mortality. The presentstudy was designed to investigate the immune mechanisms possibly involved in the amelioration of histopathologicalchanges in livers of Schistosoma mansoni infected mice treated with Nigella sativa oil combined with artemether (ART)or praziquantel (PZQ). Hitological alterations of liver and granulomas diameter were recorded. Total serumimmunoglobulin G (IgG) and cytokine profils; IL-2, IL-12 and TNF-α were studied. The levels of total serum IgG aftertreatment with N. sativa or ART or PZQ of non-infected mice recorded a significant decrease compared to normalcontrol group. While N. sativa combined with ART or PZQ of infected groups showed significant increase in total IgG(684.24 ± 3.03, 647.42 ± 2.21 and 708.50 ± 18.06, respectively) compared to infected lab control group (570.84 ± 6.55).Effect of N. sativa oil on cytokines IL-2 and TNF-α of non-infected and infected mice showed significant increase(P<0.001, Kruskal wallis). While treatment with ART of non-infected showed significant decrease in IL-2 and 12 andincrease in TNF-α. PZQ treatment showed significant increase in IL-2 and decrease in IL-12 compared to normal controlgroup. Effect of N. sativa oil combined with ART or PZQ showed significant increase on cytokines (IL-2, IL-12 andTNF-α) compared to infected control group. Histological observation of liver tissue of infected and non-infected micetreated with N. sativa combined with ART or PZQ showed some improvement in histological damages in all treatedgroups. The present data recorded that N. sativa combined with ART or PZQ recorded a significant decrease ingranuloma diameter (35.42 % and 32.23 %), when compared to infected control group. It can be concluded that N. sativais a promising adjuvant with antihelminthic drugs in the treatment of schistosomiasis.
机译：血吸虫病是世界上最流行的寄生虫病之一，也是发病和死亡的原因。本研究旨在研究可能的免疫机制，该机制可能与用Negella sativa油联合蒿甲醚（ART）或吡喹酮（PZQ）治疗的曼氏血吸虫感染小鼠的肝脏病理改变有关。记录肝脏和肉芽肿直径的病理学改变。血清总免疫球蛋白G（IgG）和细胞因子谱;研究了IL-2，IL-12和TNF-α。与正常对照组相比，用N. sativa或ART或PZQ处理的未感染小鼠后的总血清IgG水平明显下降。与感染的实验室对照组（570.84±6.55）相比，N。sativa联合ART或PZQ感染组显示总IgG显着增加（分别为684.24±3.03、647.42±2.21和708.50±18.06）。未感染和感染的小鼠的细胞因子IL-2和TNF-α上的油脂含量显着增加（P <0.001，克鲁斯卡尔沃利斯）。未感染的ART治疗显示IL-2和12显着降低，TNF-α升高。与正常对照组相比，PZQ治疗显示IL-2明显升高，IL-12降低。与感染的对照组相比，紫花苜蓿油联合ART或PZQ的作用对细胞因子（IL-2，IL-12和TNF-α）的影响明显增加。用N. sativa结合ART或PZQ处理的感染和未感染小鼠的肝组织的组织学观察显示，所有治疗组的组织学损伤均有一定程度的改善。目前的数据表明，与感染的对照组相比，紫花苜蓿与ART或PZQ联合使用可显着降低肉芽肿直径（分别为35.42％和32.23％）。可以得出结论，N。sativa是抗血吸虫病药物在血吸虫病治疗中的有前途的佐剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号