Depression-serotonin, preclinic researchs

Simsek S A

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Depression-serotonin, preclinic researchs

机译：抑郁症5-羟色胺，临床前研究

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Animal behavioural models of depression cannot exactly stimulate human psychopathology, but they can be used to evaulate behavioural changes induced by drugs and to suggest hypothesis about the function of the central nervous system and its involvement in depression. Human depression cannot be induced in animals, so the models cannot beclaimed to reproduce human psychopathology, but they are intended to induce changes that are sensitive to therapeutic agents, in a manner predictive of their effects in humans. This article summarizes the animal models of depression, their validity and the involvement of serotonin (5-HT) and other neurotransmitters to these models.

机译：抑郁症的动物行为模型不能完全刺激人类的心理病理学，但可以用来逃避药物引起的行为改变，并提出有关中枢神经系统功能及其参与抑郁症的假设。无法在动物中诱发人的抑郁症，因此不能称其为模型来重现人的心理病理学，但它们旨在以对人类治疗有影响的方式来诱导对治疗剂敏感的变化。本文概述了抑郁症的动物模型，它们的有效性以及5-羟色胺（5-HT）和其他神经递质与这些模型的关系。

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《Bulletin of Clinical Psychopharmacology》 |1993年第1期|共9页
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Simsek S A;
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中图分类神经病学与精神病学;
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Depression-serotonin, preclinic researchs

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