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首页> 外文期刊>Cancer Cell International >Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance
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Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance

机译：β-catenin，TCF-4和survivin在鼻咽癌中的作用：与临床病理特征和预后的关系

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Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin, TCF-4, and survivin affects clinicopathological features and prognostic significance in NPC. We enrolled 164 patients with NPC and 70 patients with chronic nasopharyngitis (CNP) in this study. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC) were conducted to evaluate the expression of β-catenin, TCF-4, and survivin. Spearman’s rank correlation analysis and Pearson correlation analysis were used to measure the correlation of β-catenin, TCF-4, and survivin. Risk factors for prognosis and survival conditions of NPC patients were analyzed by Cox proportional hazards model and Kaplan–Meier curves. The results obtained revealed that mRNA and protein expression of β-catenin, TCF-4, and survivin was higher in NPC tissues than in CNP tissues. Positive correlations amongst β-catenin, TCF-4, and survivin were identified by Spearman’s rank correlation analysis and Pearson correlation analysis. There was a significant correlation in expression of β-catenin, TCF-4, and survivin with EBV DNA, EBV-VCA-IgA, EBV-EA-IgA, T stage, N stage, and clinicopathological stages. Lower overall survival (OS), distant metastasis-free survival (DMFS), local recurrence-free survival (LRFS), and disease-free survival (DFS) rates were detected in NPC patients with positive expression of β-catenin, TCF-4, and survivin, in contrast to those with negative expression. Cox proportional hazards model demonstrated that β-catenin, TCF-4, and survivin protein positive expression were independent risk factors for OS and DFS of NPC prognosis; there was an evident correlation between clinicopathological stages, TCF-4, and EBV-EA-IgA and OS, DMFS, LRFS, and DFS of NPC. The aforementioned results indicate that β-catenin, TCF-4, and survivin proteins are highly expressed in NPC, which can be used as factors to predict the malignancy of NPC. In addition, positive expression of β-catenin, TCF-4, and survivin are potential risk factors that lead to an unfavorable prognosis of OS and DFS in NPC patients.
机译：鼻咽癌（NPC）是头颈部常见的恶性肿瘤，其进展和预后知之甚少。本研究旨在探讨β-catenin，TCF-4和survivin的表达是否影响NPC的临床病理特征和预后意义。在这项研究中，我们纳入了164例NPC和70例慢性鼻咽炎（CNP）患者。进行了逆转录定量聚合酶链反应（RT-qPCR）和免疫组化（IHC）以评估β-catenin，TCF-4和survivin的表达。使用Spearman秩相关分析和Pearson相关分析来测量β-catenin，TCF-4和survivin的相关性。通过Cox比例风险模型和Kaplan-Meier曲线分析了NPC患者的预后和生存状况的危险因素。获得的结果表明，NPC组织中β-catenin，TCF-4和survivin的mRNA和蛋白表达高于CNP组织。通过Spearman秩相关分析和Pearson相关分析确定了β-catenin，TCF-4和survivin之间的正相关。 β-catenin，TCF-4和survivin的表达与EBV DNA，EBV-VCA-IgA，EBV-EA-IgA，T期，N期和临床病理分期存在显着相关性。在β-catenin，TCF-4阳性表达的NPC患者中，发现总生存率（OS），远处无转移生存率（DMFS），无局部复发生存率（LRFS）和无病生存率（DFS） ，和survivin，与阴性表达的相比。 Cox比例风险模型表明，β-catenin，TCF-4和survivin蛋白阳性表达是NPC预后OS和DFS的独立危险因素。临床病理分期，TCF-4和EBV-EA-IgA与NPC的OS，DMFS，LRFS和DFS之间存在明显的相关性。上述结果表明，β-catenin，TCF-4和survivin蛋白在NPC中高度表达，可作为预测NPC恶性程度的因素。此外，β-catenin，TCF-4和survivin的阳性表达是导致NPC患者OS和DFS预后不良的潜在危险因素。

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