...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Growth and Metastasis >BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis
【24h】

BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis

机译：BITC使胰腺腺癌对TRAIL诱导的细胞凋亡敏感。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pancreatic adenocarcinoma is an aggressive cancer with a greater than 95% mortality rate and short survival after diagnosis. Chemotherapeutic resistance hinders successful treatment. This resistance is often associated with mutations in codon 12 of the K-Ras gene (K-Ras 12), which is present in over 90% of all pancreatic adenocarcinomas. Codon 12 mutations maintain Ras in a constitutively active state leading to continuous cellular proliferation. Our study determined if TRAIL resistance in pancreatic adenocarcinomas with K-Ras 12 mutations could be overcome by first sensitizing the cells with Benzyl isothiocyanate (BITC). BITC is a component of cruciferous vegetables and a cell cycle inhibitor. BxPC3, MiaPaCa2 and Panc-1 human pancreatic adenocarcinoma cell lines were examined for TRAIL resistance. Our studies show BITC induced TRAIL sensitization by dual activation of both the extrinsic and intrinsic apoptotic pathways.
机译：胰腺腺癌是一种侵袭性癌症，死亡率高于95％，诊断后生存期短。化疗耐药性阻碍了成功的治疗。这种抗性通常与K-Ras基因密码子12（K-Ras 12）的突变有关，该突变存在于所有胰腺腺癌的90％以上。密码子12突变将Ras维持在组成型活性状态，从而导致连续的细胞增殖。我们的研究确定是否可以通过首先用异硫氰酸苄酯（BITC）敏化细胞来克服具有K-Ras 12突变的胰腺腺癌的TRAIL抗性。 BITC是十字花科蔬菜的成分和细胞周期抑制剂。检查BxPC3，MiaPaCa2和Panc-1人胰腺腺癌细胞系对TRAIL的抵抗力。我们的研究表明，BITC通过外在和内在凋亡途径的双重激活诱导TRAIL致敏。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号