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Repopulation of Ovarian Cancer Cells After Chemotherapy

机译：化疗后卵巢癌细胞的重新聚集

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The high mortality rate caused by ovarian cancer has not changed for the past thirty years. Although most patients diagnosed with this disease respond to cytoreductive surgery and platinum-based chemotherapy and undergo remission, foci of cells almost always escape therapy, manage to survive, and acquire the capacity to repopulate the tumor. Repopulation of ovarian cancer cells that escape front-line chemotherapy, however, is a poorly understood phenomenon. Here I analyze cancer-initiating cells, transitory senescence, reverse ploidy, and cellular dormancy as putative players in ovarian cancer cell repopulation. As part of the standard of care, ovarian cancer patients do not receive treatment between primary cytotoxic therapy and clinical relapse. Understanding the mechanisms driving cellular escape from chemotherapy should lead to the development of low toxicity, chronic treatment approaches that can be initiated right after primary therapy to interrupt cell repopulation and disease relapse by keeping it dormant and, therefore, subclinical.
机译：在过去的三十年中，由卵巢癌引起的高死亡率没有改变。尽管大多数诊断出患有这种疾病的患者对细胞减灭术和基于铂的化学疗法有反应并获得缓解，但细胞灶几乎总是逃脱疗法，设法存活并获得使肿瘤重新繁殖的能力。然而，逃避一线化疗的卵巢癌细胞重新聚集是一个鲜为人知的现象。在这里，我分析了卵巢癌细胞再生中假定的参与者，癌症起始细胞，短暂衰老，反向倍性和细胞休眠。作为护理标准的一部分，卵巢癌患者在原发性细胞毒性治疗与临床复发之间不接受治疗。了解驱动化学疗法使细胞逃逸的机制应导致开发低毒性的慢性治疗方法，这些方法可以在主要治疗后立即开始，以通过使其处于休眠状态（因此处于亚临床状态）来中断细胞繁殖和疾病复发。

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