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Prevalence and risk factors for mast cell tumours in dogs in England

机译：英国犬肥大细胞肿瘤的患病率和危险因素

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BackgroundMast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk factors for MCTs in dogs attending English primary-care veterinary practices. MethodsElectronic patient records from practices participating in the VetCompass animal surveillance project between July 2007 and June 2013 were searched for MCT diagnosis. Various search terms and standard diagnostic terms (VeNom codes) identified records containing MCT diagnoses, which were evaluated against clinical criteria for inclusion to the study. MCT prevalence for the entire dataset and specific breed types were calculated. Descriptive statistics characterised MCT cases and multivariable logistic regression methods evaluated risk factors for association with MCT (P? ResultsWithin a population of 168,636 dogs, 453 had MCT, yielding a prevalence of 0.27% (95% confidence interval (CI) 0.24% - 0.29%). The highest breed type specific prevalences were for the Boxer at 1.95% (95% CI 1.40% - 2.51%), Golden Retriever at 1.39% (0.98% - 1.81%) and Weimaraner at 0.85% (95% CI 0.17% to 1.53%). Age, insurance status, neuter status, weight and breed type were associated with MCT diagnosis. Of dogs of specific breed type, the Boxer, Pug and Staffordshire Bull Terrier showed greater odds of MCT diagnosis compared with crossbred dogs. Conversely, the German Shepherd Dog, Border Collie, West Highland White Terrier, Springer Spaniel and Cocker Spaniel had reduced odds of MCT diagnosis compared with crossbred dogs. No association was found between MCT diagnosis and sex. Clinical significanceThis study highlights a clinically significant prevalence of MCT and identifies specific breed types with predisposition to MCT, potentially aiding veterinarian awareness and facilitating diagnosis.
机译：背景肥大细胞瘤（MCT）在狗中似乎是一种常见的肿瘤类型，尽管在英国，关于其频率的报道很少。当前的研究旨在调查接受英国初级保健兽医实践的狗中MCT的患病率和危险因素。方法检索2007年7月至2013年6月期间参加VetCompass动物监视项目的实践中的电子病历，以进行MCT诊断。各种搜索词和标准诊断词（VeNom代码）确定了包含MCT诊断的记录，并根据临床标准对其进行了评估，以纳入研究。计算了整个数据集和特定品种类型的MCT患病率。描述性统计数据以MCT病例为特征，多变量Logistic回归方法评估了与MCT相关的危险因素（P？结果）在168,636只狗中，有453例患有MCT，患病率为0.27％（95％置信区间（CI）0.24％-0.29％ ）。最高的品种类型患病率是：拳击手（1.95％（95％CI 1.40％-2.51％），金毛猎犬（1.39％（0.98％-1.81％））和魏玛拉纳（0.85％（95％CI 0.17％至1.53％）。年龄，保险状况，中性状态，体重和品种类型与MCT诊断有关，在特定品种类型的犬中，与杂交犬相比，Boxer，Pug和Staffordshire斗牛犬的MCT诊断几率更高。与杂交犬相比，德国牧羊犬，博德牧羊犬，西部高地白梗，史宾格犬和可卡犬的MCT诊断几率降低，MCT诊断与性别之间没有关联。 MCT的流行率很高，并且可以识别具有MCT易感性的特定品种类型，从而可能有助于提高兽医的意识并促进诊断。

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