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首页> 外文期刊>Cardiovascular Diabetology >Translating recent results from the Cardiovascular Outcomes Trials into clinical practice: recommendations from the Central and Eastern European Diabetes Expert Group (CEEDEG)
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Translating recent results from the Cardiovascular Outcomes Trials into clinical practice: recommendations from the Central and Eastern European Diabetes Expert Group (CEEDEG)

机译：将心血管结果试验的最新结果转化为临床实践：中欧和东欧糖尿病专家组（CEEDEG）的建议

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These recommendations aim to improve care for patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk in Central and Eastern Europe. Cardiovascular disease (CVD) and/or chronic kidney disease (CKD) are major interdependent comorbidities in patients with T2D, accounting for 50% of mortality. Following recent CV outcomes trial (CVOT) results, including those from EMPA-REG OUTCOME?, LEADER?, SUSTAIN?-6 and, most recently, the CANVAS study, it is essential to develop regional expert consensus recommendations to aid physicians in interpreting these newest data to clinical practice. The Central and Eastern European Diabetes Expert Group (CEEDEG) followed a Delphi method to develop treatment algorithms to aid physicians in the clinical management of patients with T2D at high CV risk. In light of the latest CVOT results, and in particular the EMPA-REG OUTCOME? and LEADER? trials, the diagnosis, assessment, treatment choice and monitoring of patients with T2D and established CVD and/or CKD have been considered together with existing guidelines and presented in two reference algorithms. In addition, adherence, special prescribing considerations and a proposed multidisciplinary management approach have been discussed and are presented with the proposed algorithms. The latest available high-level evidence on glucose-lowering drugs has enabled CEEDEG to develop practical consensus recommendations for patients with established CVD and/or CKD. These recommendations represent an update to international and country-level guidelines used for these patients, with the aim of providing a resource not only to endocrinologists, but to cardiologists, nephrologists and primary care physicians in the region.
机译：这些建议旨在改善中欧和东欧具有高心血管（CV）风险的2型糖尿病（T2D）患者的护理。心血管疾病（CVD）和/或慢性肾脏病（CKD）是T2D患者的主要相互依存合并症，占死亡率的50％。继最近的CV结果试验（CVOT）结果（包括EMPA-REG OUTCOME？，LEADER？，SUSTAIN？-6）以及最近的CANVAS研究结果之后，制定区域专家共识建议以帮助医师解释这些建议至关重要临床实践的最新数据。中欧和东欧糖尿病专家组（CEEDEG）遵循了Delphi方法来开发治疗算法，以帮助医生对高CV风险的T2D患者进行临床管理。根据最新的CVOT结果，尤其是EMPA-REG结果？和领导者？试验，诊断，评估，治疗选择和监测T2D和已建立的CVD和/或CKD的患者已与现有指南一起考虑，并以两种参考算法提出。此外，还讨论了依从性，特殊的处方注意事项和提议的多学科管理方法，并与提出的算法一起提出。关于降糖药物的最新可用高级证据使CEEDEG能够为已建立CVD和/或CKD的患者制定实用的共识性建议。这些建议代表了针对这些患者的国际和国家/地区级指南的更新，其目的不仅是为内分泌科医生提供资源，而且还为该地区的心脏病医生，肾脏病医生和初级保健医生提供资源。

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