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首页> 外文期刊>Cardiovascular Diabetology >Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence–young adulthood cardiometabolic risk markers
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Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence–young adulthood cardiometabolic risk markers

机译：从儿童期到青春期后期以及随后的青春期–青年成年期心脏代谢风险标志物的体重指数发展轨迹

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Reports on body mass index (BMI) trajectories from childhood into late adolescence, their determinants, and subsequent cardiometabolic risk markers, particularly among European populations have been few. Moreover, sex-specific investigation is necessary considering the sex difference in BMI, and the sex-specific association between BMI and some cardiometabolic risk markers. Using a sample from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study, we explored sex-specific trajectories of the BMI standard deviation score (SDS) from 4 to 18?years of age in 354 males and 335 females by latent (class) growth models. The determinants of trajectory were assessed by logistic regression. We identified cardiometabolic risk markers that were highly associated with BMI SDS trajectory by random forest regression, and finally we used generalized linear models to investigate differences in the identified cardiometabolic risk markers between pairs of trajectories. We observed four: ‘low-normal weight’, ‘mid-normal weight’, ‘high-normal weight’, and ‘overweight’, and three: ‘‘low-normal weight’, ‘mid-normal weight’, and ‘high-normal weight’ trajectories in males and females, respectively. Higher maternal prepregnancy BMI was associated with the ‘overweight’ trajectory, and with ‘high-normal weight’ trajectory in both sexes. In addition, employed mothers and first-born status were associated with ‘high-normal weight’ trajectory in females. BMI SDS trajectory was associated with high-density lipoprotein-cholesterol and interleukin-18 (IL-18) in males, and diastolic blood pressure and interleukin-6 (IL-6) in females. However, only males following the ‘overweight’ trajectory had significantly higher IL-18 when compared to their ‘low-normal weight’ counterpart. We identified sex-specific distinct trajectories of BMI SDS from childhood into late adolescence, higher maternal prepregnancy BMI as a common determinant of the ‘high-normal weight’ and ‘overweight’ trajectories, and ‘overweight’ trajectory being associated with elevated IL-18 in late adolescence–young adulthood. This study emphasizes the role of maternal prepregnancy BMI in overweight, and highlights IL-18 as a cardiometabolic signature of overweight across life.
机译：关于从儿童期到青春期晚期的体重指数（BMI）轨迹，其决定因素以及随后的心脏代谢风险标志（尤其是在欧洲人群中）的报告很少。此外，有必要进行针对性别的调查，考虑到BMI的性别差异以及BMI与某些心脏代谢风险标志物之间的性别关联。我们使用来自多特蒙德营养与人体测量学纵向设计研究的样本，通过潜伏（类）生长模型探索了354位男性和335位女性在4至18岁时BMI标准偏差得分（SDS）的性别特异性轨迹。轨迹的决定因素通过逻辑回归进行评估。我们通过随机森林回归分析确定了与BMI SDS轨迹高度相关的心脏代谢危险标志物，最后，我们使用广义线性模型研究了轨迹对之间识别出的心脏代谢危险标志物的差异。我们观察到四个：“低正常体重”，“中正常体重”，“高正常体重”和“超重”，以及三个：“低正常体重”，“中正常体重”和“男性和女性的高体重正常轨迹。孕产妇较高的BMI与“超重”轨迹和“高正常体重”轨迹相关。此外，受雇的母亲和第一胎的状况与女性的“高体重正常”轨迹有关。男性的BMI SDS轨迹与高密度脂蛋白胆固醇和白细胞介素18（IL-18）以及女性的舒张压和白细胞介素6（IL-6）有关。但是，只有遵循“超重”轨迹的男性的“ IL-18”水平明显高于“低正常体重”的男性。我们确定了从儿童期到青春期的BMI SDS的性别差异轨迹，母亲较高的孕前BMI是“正常体重”和“超重”轨迹的共同决定因素，而“超重”轨迹与IL-18升高相关在青春期末期-年轻成年。这项研究强调了孕前BMI在超重中的作用，并强调了IL-18是一生中超重的心脏代谢指标。

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