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首页> 外文期刊>Case Reports in Dermatological Medicine >Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy
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Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy

机译：复发性转移性乳腺外佩吉特病对曲妥珠单抗单一疗法的戏剧性临床反应

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We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget’s disease that showed the validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg maintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete response was achieved after the tenth infusion. The patient experienced a moderate headache and flushing during the first infusion, but had no advanced effects during subsequent infusions with ibuprofen and d-chlorpheniramine maleate. Given the dramatic response, the patient has had 17 infusions of trastuzumab with no disease progression. Thus, trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.
机译：我们报道了第一例68岁的日本女性，患有转移性HER2阳性乳腺Paget病，这显示了曲妥珠单抗单一疗法的有效性。根据HER2阳性转移性乳腺癌的治疗方案，我们以8μmg/ kg i.v.的负荷剂量给予曲妥珠单抗，然后每三周给予6μmg/ kg维持剂量，第十次输注后达到了接近完全的反应。该患者在第一次输注时出现了中度头痛和潮红，但在随后输注布洛芬和马来酸d-氯苯那敏时没有晚期效果。鉴于反应迅速，患者已输注了曲妥珠单抗17次，无疾病进展。因此，曲妥珠单抗几乎没有副作用，并且对老年患者具有良好的耐受性。它可能成为该疾病辅助治疗的新选择。

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