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Viral interactions with intermediate filaments: Paths less explored

机译：病毒与中间丝的相互作用：探索途径较少

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Abstract: The limited repertoire of viruses led to their exploitation of cellular machinery for various events in virus replication, starting from entry till egress. The major cellular contributors in this process are the cytoskeletal components, which serve as entry points into the cells and also as tracks and highways to reach the replication sites. The role of microfilaments and microtubules, two of the major cytoskeletal elements have been extensively studied with respect to virus replication. However, very little is known about the third component, the intermediate filaments. This could in part be due to the intermediate filaments having long been thought to be rigid structures providing mechanical support to the cells. With the increasing knowledge of the dynamic property of intermediate filaments, (owing to their association with microfilaments and microtubules) their role in membrane trafficking and endocytosis, uncovered, the idea that viruses might be exploiting these cytoskeletal elements is gaining impetus. In this review, we have attempted to link viruses with the intermediate filaments, as we believe that intermediate filaments might also be important for virus replication.
机译：摘要：有限的病毒库导致他们利用细胞机制来进行从复制到进入的各种病毒复制事件。在此过程中，主要的细胞贡献者是细胞骨架成分，它们既是进入细胞的入口点，又是到达复制位点的轨道和高速公路。关于病毒复制，已经广泛研究了微丝和微管的作用，这是两个主要的细胞骨架元件。但是，对第三组分即中间丝的了解很少。这可能部分是由于长期以来人们一直认为中间细丝是为电池提供机械支撑的刚性结构。随着对中间丝的动态特性的了解不断增加（由于它们与微丝和微管的结合），它们在膜运输和内吞作用中的作用被发现，病毒可能正在利用这些细胞骨架成分的想法得到了推动。在本文中，我们尝试将病毒与中间丝连接在一起，因为我们认为中间丝对于病毒复制也可能很重要。

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