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Current perspectives on cadherin-cytoskeleton interactions and dynamics

机译:钙粘蛋白-细胞骨架相互作用和动力学的当前观点

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Abstract: Cells are linked together dynamically by adhesion molecules, such as the classical cadherins. E-cadherin, which mediates epithelial cell–cell interactions, plays fundamental roles in tissue organization and is often perturbed in diseases such as cancer. It has long been recognized that the biology of E-cadherin arises from cooperation between adhesion and the actin cytoskeleton.A major feature is the generation of contractile forces at junctions, yielding patterns of tension that contribute to tissue integrity and patterning. Here we discuss recent developments in understanding how cadherin junctions integrate signaling and cytoskeletal dynamics to sense and generate force.
机译:摘要:细胞通过粘附分子(例如经典的钙黏着蛋白)动态连接在一起。 E-钙粘着蛋白介导上皮细胞之间的相互作用,在组织组织中起着基本作用,并且经常在诸如癌症等疾病中受到干扰。长期以来,人们一直认识到E-钙粘蛋白的生物学起源于粘附和肌动蛋白细胞骨架之间的合作。一个主要特征是在连接处产生收缩力,产生的张力模式有助于组织的完整性和模式。在这里,我们讨论了了解钙粘蛋白连接如何整合信号传导和细胞骨架动力学以感测和产生力的最新进展。

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