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首页> 外文期刊>Cellular Oncology: Analytical Cellular Pathology >Dependence of DNA-Histograms on The Sampling Techniques in Fine Needle Aspirates of the Breast
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Dependence of DNA-Histograms on The Sampling Techniques in Fine Needle Aspirates of the Breast

机译：DNA直方图对乳房细针抽吸物采样技术的依赖性

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48 fine needle aspiration biopsy (FNAB) samples from 25 breast cancer cases, originally used for cytodiagnosis were subjected to DNA cytometry. There were air dried smears stained with the MGG method, and samples stained with HE or PAP stain after 50% ethanol fixation and cytocentrifugation. Different sampling strategies were applied. Four methods were tested: method 1: cell groups measured, method 2: all cells measured, method 3: free cells measured, and method 4: atypical free cells measured. Method 4 showed most often DNA aneuploid histogram patterns, sampling method 1 had the highest number of DNA diploid histogram patterns. Diagnostic approaches may benefit from a sampling method detecting the hiding aneuploid cell population. Grading of neoplasm could potentially benefit from other approaches.
机译：对来自25例最初用于细胞诊断的乳腺癌病例的48例细针穿刺活检（FNAB）样本进行了DNA细胞计数。风干的涂片用MGG方法染色，样品在50％乙醇固定和细胞离心后用HE或PAP染色。应用了不同的采样策略。测试了四种方法：方法1：测量的细胞组，方法2：测量的所有细胞，方法3：测量的游离细胞，方法4：测量的非典型游离细胞。方法4最常显示DNA非整倍体直方图，采样方法1具有最多的DNA二倍体直方图。诊断方法可能受益于检测隐藏的非整倍体细胞群体的采样方法。肿瘤分级可能会从其他方法中受益。

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