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p27kip1 at the crossroad between actin and microtubule dynamics

机译：p27kip1在肌动蛋白和微管动力学之间的十字路口

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The p27kip1 protein, mainly known as a negative regulator of cell proliferation, has also been involved in the control of other cellular processes, including the regulation of cytoskeleton dynamics. Notably, these two functions involve distinct protein domains, residing in the N- and C-terminal halves, respectively. In the last two decades, p27kip1 has been reported to interact with microtubule and acto-myosin cytoskeletons, both in direct and indirect ways, overall drawing a picture in which several factors play their role either in synergy or in contrast one with another. As a result, the role of p27kip1 in cytoskeleton dynamics has been implicated in cell migration, both in physiologic and in neoplastic contexts, modulating cytokinesis, lipid raft trafficking, and neuronal development. Recently, two distinct papers have further reported a central role for p27kip1 in the control of microtubule stability and post-translational modifications, dissecting the interaction between p27kip1 and α-tubulin-acetyl-transferase (α-TAT), an enzyme involved in the stability of microtubules, and protein-regulator of cytokinesis 1 (PRC1), a nuclear regulator of the central spindle during mitosis. In light of these recent evidences, we will comment on the role of p27kip1 on cytoskeleton regulation and its implication for cancer progression.
机译：p27kip1蛋白主要被称为细胞增殖的负调节剂，也参与了其他细胞过程的控制，包括细胞骨架动力学的调节。值得注意的是，这两个功能涉及不同的蛋白质结构域，分别位于N末端和C末端一半。在过去的二十年中，据报道p27kip1以直接和间接的方式与微管和肌动球蛋白肌动蛋白细胞骨架相互作用，总体上描绘出了其中一些因素在协同作用中或与另一因素形成对比时发挥作用的图景。结果，p27kip1在细胞骨架动力学中的作用与生理和肿瘤情况下的细胞迁移，调节细胞分裂，脂质筏运输和神经元发育有关。最近，两篇不同的论文进一步报道了p27kip1在控制微管稳定性和翻译后修饰中的核心作用，剖析了p27kip1与α-微管蛋白-乙酰基转移酶（α-TAT）（一种参与该稳定性的酶）之间的相互作用微管和胞质分裂1（PRC1）的蛋白质调节剂，有丝分裂期间中央纺锤体的核调节剂。根据这些最新证据，我们将评论p27kip1在细胞骨架调控中的作用及其对癌症进展的影响。

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