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A History of Gap Junction Structure: Hexagonal Arrays to Atomic Resolution

机译:间隙连接结构的历史:六边形阵列的原子分辨率。

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Gap junctions are specialized membrane structures that provide an intercellular pathway for the propagation and/or amplification of signaling cascades responsible for impulse propagation, cell growth, and development. Prior to the identification of the proteins that comprise gap junctions, elucidation of channel structure began with initial observations of a hexagonal nexus connecting apposed cellular membranes. Concomitant with technological advancements spanning over 50 years, atomic resolution structures are now available detailing channel architecture and the cytoplasmic domains that have helped to define mechanisms governing the regulation of gap junctions. Highlighted in this review are the seminal structural studies that have led to our current understanding of gap junction biology.
机译:间隙连接是专门的膜结构,其为负责脉冲传播,细胞生长和发育的信号级联反应的增殖和/或扩增提供了细胞间途径。在鉴定包含间隙连接的蛋白质之前,首先对连接细胞膜的六边形连接进行初步观察来阐明通道结构。伴随着50多年的技术进步,原子分辨率结构现已面世,详细介绍了通道结构和细胞质结构域,这些结构有助于定义控制间隙连接调节的机制。这篇综述中突出的是精髓的结构研究,这些研究导致了我们对间隙连接生物学的当前理解。

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