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首页> 外文期刊>Cell communication & adhesion >150th Anniversary Series: Desmosomes and the Hallmarks of Cancer
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150th Anniversary Series: Desmosomes and the Hallmarks of Cancer

机译：150周年纪念系列：桥粒和癌症的标志

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Desmosomes represent adhesive, spot-like intercellular junctions that in association with intermediate filaments mechanically link neighboring cells and stabilize tissue architecture. In addition to this structural function, desmosomes also act as signaling platforms involved in the regulation of cell proliferation, differentiation, migration, morphogenesis, and apoptosis. Thus, deregulation of desmosomal proteins has to be considered to contribute to tumorigenesis. Proteolytic fragmentation and downregulation of desmosomal cadherins and plaque proteins by transcriptional or epigenetic mechanisms were observed in different cancer entities suggesting a tumor-suppressive role. However, discrepant data in the literature indicate that context-dependent differences based on alternative intracellular, signal transduction lead to altered outcome. Here, modulation of Wnt/β-catenin signaling by plakoglobin or desmoplakin and of epidermal growth factor receptor signaling appears to be of special relevance. This review summarizes current evidence on how desmosomal proteins participate in carcinogenesis, and depicts the molecular mechanisms involved.
机译：桥粒代表粘附的，斑点样的细胞间连接，其与中间细丝相关联以机械方式连接相邻细胞并稳定组织结构。除此结构功能外，桥粒还充当参与调节细胞增殖，分化，迁移，形态发生和凋亡的信号传递平台。因此，必须考虑桥粒蛋白的失调有助于肿瘤的发生。在不同的癌症实体中观察到通过转录或表观遗传机制的蛋白水解片段化和桥粒钙粘蛋白和噬菌斑蛋白的下调，表明其具有肿瘤抑制作用。但是，文献中的差异数据表明，基于细胞内信号转导的上下文相关差异会导致结果改变。在此，通过斑白蛋白或去铁铂对Wnt /β-catenin信号传导的调节以及对表皮生长因子受体信号传导的调节似乎具有特殊的意义。这篇综述总结了有关桥粒蛋白如何参与致癌作用的最新证据，并描述了所涉及的分子机制。

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