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Cyclin-dependent kinases in C. elegans

机译：线虫中细胞周期蛋白依赖性激酶

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Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell-cycle machinery has been identified, and a major challenge in coming years will be to understand the complex interplay between cell division and multicellular development. Inevitably, this requires the use of more complex multicellular model systems. The small nematode Caenorhabditis elegans is an excellent model system to study the regulation of cell division in a multicellular organism, and is poised to make important contributions to this field. The past decade has already seen a surge in cell-cycle research in C. elegans, yielding information on the function of many basic cell-cycle regulators, and making inroads into the developmental control of cell division. This review focuses on the in vivo roles of cyclin-dependent kinases in C. elegans, and highlights novel findings implicating CDKs in coupling development to cell-cycle progression.
机译：细胞分裂是有机体发育的固有部分，该过程中的缺陷会导致发育异常以及癌性生长。在过去的几十年中，已经确定了许多基本的细胞周期机制，并且未来几年的主要挑战将是了解细胞分裂与多细胞发育之间的复杂相互作用。不可避免地，这需要使用更复杂的多细胞模型系统。小型线虫秀丽隐杆线虫是研究多细胞生物中细胞分裂调控的优秀模型系统，并有望在该领域做出重要贡献。在过去的十年中，秀丽隐杆线虫的细胞周期研究激增，产生了许多基本细胞周期调节因子功能的信息，并进军细胞分裂的发育控制。这篇综述着重于线虫中细胞周期蛋白依赖性激酶的体内作用，并强调了涉及CDK与细胞周期进程耦合发展的新发现。

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