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Mitotic regulation by NIMA-related kinases

机译：NIMA相关激酶对有丝分裂的调节

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The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast homologue Fin1, contribute to multiple aspects of mitotic progression including the timing of mitotic entry, chromatin condensation, spindle organization and cytokinesis. Mammals contain a large family of eleven NIMA-related kinases, named Nek1 to Nek11. Of these, there is now substantial evidence that Nek2, Nek6, Nek7 and Nek9 also regulate mitotic events. At least three of these kinases, as well as NIMA and Fin1, have been localized to the microtubule organizing centre of their respective species, namely the centrosome or spindle pole body. Here, they have important functions in microtubule organization and mitotic spindle assembly. Other Nek kinases have been proposed to play microtubule-dependent roles in non-dividing cells, most notably in regulating the axonemal microtubules of cilia and flagella. In this review, we discuss the evidence that NIMA-related kinases make a significant contribution to the orchestration of mitotic progression and thereby protect cells from chromosome instability. Furthermore, we highlight their potential as novel chemotherapeutic targets.
机译：NIMA相关激酶代表与细胞周期控制有关的丝氨酸/苏氨酸激酶家族。该家族的创始成员，构巢曲霉的NIMA激酶，以及裂变酵母同源物Fin1，对有丝分裂进程的多个方面做出了贡献，包括有丝分裂进入的时间，染色质凝聚，纺锤体组织和胞质分裂。哺乳动物包含11个与NIMA相关的激酶的大家族，称为Nek1至Nek11。其中，现在有大量证据表明Nek2，Nek6，Nek7和Nek9也调节有丝分裂事件。这些激酶中的至少三种以及NIMA和Fin1已定位于它们各自物种的微管组织中心，即中心体或纺锤体。在这里，它们在微管组织和有丝分裂纺锤体组装中具有重要功能。已经提出其他Nek激酶在非分裂细胞中起微管依赖性作用，最显着地是在调节纤毛和鞭毛的轴突微管中。在这篇综述中，我们讨论了NIMA相关激酶对有丝分裂进程编排的重要贡献，从而保护细胞免受染色体不稳定的影响的证据。此外，我们强调了它们作为新型化学治疗靶标的潜力。

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