• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell Division >Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1
【24h】

Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1

机译：维持基因组完整性的新颖见解：Wee1调节Mus81 / Eme1

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Maintenance of genomic integrity is essential for cell survival. Specifically, during DNA replication cells use a complex network of mechanisms that prevents genomic instability. Recently, we and others identified Wee1, a serine/threonine and tyrosine kinase, as a new modulator of the genomic stability during S phase. Loss of its activity causes a general DNA damage response activation and a decrease in replication fork speed. These effects are counteracted by the downregulation of the endonuclease complex Mus81-Eme1, showing a new link between this endonuclease and Wee1 during DNA replication. Here we discuss the function of Wee1 in genomic stability and its relationship with the Mus81-Eme1 complex.
机译：维持基因组完整性对于细胞存活至关重要。具体而言，在DNA复制期间，细胞使用了复杂的机制网络来防止基因组不稳定。最近，我们和其他人确定Wee1，一种丝氨酸/苏氨酸和酪氨酸激酶，是S期基因组稳定性的新调节剂。其活性的丧失导致一般的DNA损伤反应激活和复制叉速度的降低。这些作用被核酸内切酶复合物Mus81-Eme1的下调所抵消，显示在DNA复制过程中该核酸内切酶与Wee1之间存在新的联系。在这里，我们讨论了Wee1在基因组稳定性中的功能及其与Mus81-Eme1复合体的关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号