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Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation

机译：细胞周期蛋白依赖性激酶2对少突胶质祖细胞增殖和分化的差异性要求

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Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle. Despite its fundamental role, Cdk2 was found to be indispensable only in specific cell types due to molecular redundancies in its function. Converging studies highlight involvement of Cdk2 and associated cell cycle regulatory proteins in oligodendrocyte progenitor cell proliferation and differentiation. Giving the contribution of this immature cell type to brain plasticity and repair in the adult, this review will explore the requirement of Cdk2 for oligodendrogenesis, oligodendrocyte progenitor cells proliferation and differentiation during physiological and pathological conditions.
机译：细胞周期蛋白依赖性激酶（Cdks）及其细胞周期蛋白调节亚单位控制细胞的生长和分裂。 Cdk2-cyclin E复合物使视网膜母细胞瘤蛋白磷酸化，驱动细胞通过G1 / S过渡进入细胞周期的S期。尽管Cdk2具有基本作用，但由于其功能上的分子冗余，发现Cdk2仅在特定细胞类型中必不可少。越来越多的研究突出了Cdk2和相关的细胞周期调控蛋白参与少突胶质祖细胞增殖和分化的过程。鉴于这种不成熟的细胞类型对成年人大脑可塑性和修复的贡献，本文将探讨Cdk2在生理和病理条件下对少突胶质生成，少突胶质祖细胞增殖和分化的需求。

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