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首页> 外文期刊>Cellular Oncology: Analytical Cellular Pathology >Genetic Classification of Oral and Oropharyngeal Carcinomas Identifies Subgroups with a Different Prognosis
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Genetic Classification of Oral and Oropharyngeal Carcinomas Identifies Subgroups with a Different Prognosis

机译：口腔和口咽癌的遗传分类确定具有不同预后的亚组

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The common risk factors for oral and oropharyngeal cancer are tobacco smoking and alcohol consumption, and recently the human papillomavirus (HPV) was shown to be involved in a subgroup. HPV-positive and -negative carcinomas can be distinguished on basis of their genetic profiles. Aim of this study was to investigate patterns of chromosomal aberrations of HPV-negative oral and oropharyngeal squamous cell carcinomas (OOSCC) in order to improve stratification of patients regarding outcome. Thirty-nine OOSCCs were classified on basis of their genetic pattern determined by array comparative genomic hybridization (aCGH). Resulting groups were related to patient and tumor characteristics using the Fisher’s exact test and in addition to survival with the Kaplan–Meier and log rank tests. Classification distinguished three groups, one characterized by hardly any chromosomal aberration (N= 8) and another by a relatively high level (N= 26), and one with a very high level (N= 5) of chromosomal aberrations. This classification was significantly (p= 0.003) associated with survival, with the best survival in the genetically ‘silent’ group and the worst survival in the most aberrant group. The silent profile was significantly (p< 0.05) associated with wild-typeTP53, an absence of alcohol consumption and a female gender. These carcinomas were negative for microsatellite instability. This classification of OOSCC was confirmed in an independent set of 89 oral carcinomas. In conclusion, the discovery of these new classes of oral and oropharyngeal cancer with unique genetic and clinical characteristics has important consequences for future basic and clinical studies.
机译：口腔癌和口咽癌的常见危险因素是吸烟和饮酒，近来，人类乳头瘤病毒（HPV）被证明与该亚组有关。 HPV阳性和阴性癌可根据其遗传特征进行区分。这项研究的目的是调查HPV阴性口腔和口咽鳞状细胞癌（OOSCC）的染色体畸变模式，以改善患者的结局。根据通过阵列比较基因组杂交（aCGH）确定的遗传模式，对39个OOSCC进行了分类。结果组使用Fisher精确检验与患者和肿瘤特征相关，此外，Kaplan-Meier和对数秩检验与存活率相关。分类区分了三组，一组的特征是几乎没有染色体畸变（N = 8），另一组的特征是相对较高的水平（N = 26），另一组的特征是非常高的染色体畸变（N = 5）。此分类与生存率显着相关（p = 0.003），在基因“沉默”组中生存率最高，而在异常组中生存率最差。沉默特征与野生型TP53，无饮酒和雌性显着相关（p <0.05）。这些癌微卫星不稳定性阴性。在一组独立的89例口腔癌中证实了OOSCC的这种分类。总之，这些具有独特的遗传和临床特征的新型口腔和口咽癌的发现对未来的基础和临床研究具有重要意义。

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