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首页> 外文期刊>Cellular Physiology and Biochemistry >Supplementation with Undenatured Whey Protein During Diabetes Mellitus Improves the Healing and Closure of Diabetic Wounds through the Rescue of Functional Long-lived Wound Macrophages
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Supplementation with Undenatured Whey Protein During Diabetes Mellitus Improves the Healing and Closure of Diabetic Wounds through the Rescue of Functional Long-lived Wound Macrophages

机译：在糖尿病期间补充未变性的乳清蛋白可通过抢救功能性长寿伤口巨噬细胞改善糖尿病伤口的愈合和闭合

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Long and persistent uncontrolled diabetes tends to degenerate the immune system and increase the incidence of infections in diabetic patients. A serious complication of diabetes is impaired healing, which diminishes physical activity and, in some cases, leads to chronic wounds and limb amputation. Whey proteins (WPs) enhance immunity during early development and have a protective role in some immune disorders. The effect of camel WPs on wound healing in a streptozotocin-induced type 1 diabetic mice model was investigated. Sixty male mice were equally distributed into 3 experimental groups group 1, non-diabetic control mice; group 2, diabetic mice; and group 3, diabetic mice that were orally supplemented with undenatured WP (100 mg/kg body weight/day for 1 month through oral gavage). We observed that the diabetic mice exhibited delayed wound closure characterized by a significant reduction in collagen deposition, prolonged elevation in inflammatory cytokines, aberrant activation of STAT3 and reduction in the activation of Akt and NF-?B when compared with the control mice. Moreover, in the diabetic mice, the wound-resident macrophages were dysfunctional and demonstrated increased apoptosis, a significant reduction in their phagocytotic ability, aberrant activation of STAT3 and a marked reduction in the activation of Akt. Interestingly, the supplementation of diabetic mice with WP significantly enhanced the collagen deposition, limited the inflammatory stimuli, restored the activation of STAT3, Akt and NF-?B and greatly improved the closure of diabetic wounds compared with the control mice. Most important, the supplementation of diabetic mice with WP rescued functional, long-lived wound-resident macrophages. Our data reveal the benefits of WP supplementation in improving the healing and closure of diabetic wounds.
机译：长期且持续的不受控制的糖尿病往往会降低免疫系统的退化，并增加糖尿病患者感染的发生率。糖尿病的严重并发症会损害康复，削弱身体活动，在某些情况下会导致慢性伤口和肢体截肢。乳清蛋白（WPs）在早期发育过程中增强免疫力，并在某些免疫疾病中起保护作用。在链脲佐菌素诱导的1型糖尿病小鼠模型中，研究了骆驼WP对伤口愈合的影响。将60只雄性小鼠平均分为3个实验组，第1组，非糖尿病对照小鼠;和3个实验组。第2组，糖尿病小鼠;和第3组，糖尿病小鼠口服未变性的WP（通过管饲法每月口服100 mg / kg体重/天，持续1个月）。我们观察到，与对照小鼠相比，糖尿病小鼠表现出伤口闭合延迟，其特征在于胶原蛋白沉积的显着减少，炎性细胞因子的延长升高，STAT3的异常激活以及Akt和NF-κB的激活减少。此外，在糖尿病小鼠中，常驻伤口的巨噬细胞功能异常并显示出凋亡增加，吞噬能力显着降低，STAT3异常激活和Akt激活显着降低。有趣的是，与对照小鼠相比，用WP补充糖尿病小鼠显着增强了胶原蛋白沉积，限制了炎性刺激，恢复了STAT3，Akt和NF-κB的活化并大大改善了糖尿病伤口的闭合性。最重要的是，用WP补充糖尿病小鼠可以拯救功能性的，长寿的伤口驻留巨噬细胞。我们的数据揭示了补充WP可以改善糖尿病伤口的愈合和闭合效果。

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