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首页> 外文期刊>Cellular Physiology and Biochemistry >Influence of Dexamethasone on Atrial Ion Currents and Their Early Ionic Tachycardia-induced Electrical Remodeling in Rabbits
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Influence of Dexamethasone on Atrial Ion Currents and Their Early Ionic Tachycardia-induced Electrical Remodeling in Rabbits

机译：地塞米松对家兔心房离子电流及其早期心动过速引起的电重构的影响

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Background Certain evidence points to a role of inflammation in AF pathophysiology. Thus, antiinflammatory treatment of AF is discussed. Effects of a dexamethasone treatment (7 days) on atrial ion currents (IsubCa,L/sub, Isubto/sub, Isubsus/sub) and their tachycardia-induced remodeling were studied in a rabbit model. Methods 6 groups of 4 animals each were built. Rapid atrial pacing (600 min) was performed for 24 and 120 hours with/ without dexamethasone treatment. Ion currents were measured using whole cell patch clamp method. Results Rapid atrial pacing reduced (IsubCa,L/sub, Isubto/sub was decreased after 24 hours but almost returned to control values after 120 hours. When dexamethasone-treated animals also underwent atrial tachypacing, pacing-induced reduction of IsubCa,L/sub was still observed after 24 hours and was even augmented after 120 hours compared to untreated but tachypaced animals. Isubto/sub was not influenced by dexamethasone alone. In dexamethasone-treated animals, reduction of Isubto/sub was not observed after 24 hours but occurred after 120 hours of atrial tachypacing. Isubsus/sub was neither influenced by rapid atrial pacing nor by dexamethasone. Biophysical properties of all currents were affected neither by rapid atrial pacing nor by dexamethasone. Conclusion Dexamethasone influenced tachycardia-induced alterations of atrial Isubto/sub. Our experiments give evidence that - amongst other anti-inflammatory action – impact of dexamethasone on ion currents and their tachycardia-induced alterations might also play a role in treatment/prevention of AF with steroids.
机译：背景技术某些证据表明炎症在房颤的病理生理中起作用。因此，讨论了AF的抗炎治疗。地塞米松治疗（7天）对心房离子电流（I Ca，L ，I 至，I sus ）及其心动过速的影响在兔模型中研究了诱导的重塑。方法建立6组，每组4只动物。在有/没有地塞米松治疗的情况下，快速心房起搏（600分钟）持续了24和120小时。使用全细胞膜片钳方法测量离子电流。结果快速心房起搏减少（I Ca，L ，I to 在24小时后降低，但在120小时后几乎恢复到对照值。地塞米松治疗的动物也进行了心房快速起搏，与未治疗但快速起搏的动物相比，在24小时后仍观察到起搏起搏诱导的I Ca，L 的降低，甚至在120小时后有所升高，对I to 的动物没有影响。在地塞米松治疗的动物中，在24小时后未观察到I to 的降低，但在心房速动120小时后出现了I to 的降低，I sus 均不受快速心房起搏或地塞米松。所有电流的生物物理特性均不受快速心房起搏或地塞米松的影响。结论地塞米松影响心动过速引起的心房I to 的改变。我们的实验表明-除其他抗发炎作用–地塞米松对离子电流和离子的影响心律失常引起的心律失常也可能在类固醇治疗/预防房颤中发挥作用。

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