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首页> 外文期刊>Cellular Physiology and Biochemistry >Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats
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Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats

机译：早期过量喂养引起的肥胖导致大鼠棕色脂肪组织功能低下

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biBackground/Aims /i/bBrown adipose tissue activation has been considered a potential anti-obesity mechanism because it is able to expend energy through thermogenesis. In contrast, white adipose tissue stores energy, contributing to obesity. We investigated whether the early programming of obesity by overfeeding during lactation changes structure of interscapular brown adipose tissue in adulthood and its effects on thermogenesis. biMethods /i/bBirth of litters was considered day 0. On day 2, litter size was adjusted to normal (9 pups) and small (3 pups) litters. On day 21, the litters were weaned. A temperature transponder was implanted underneath interscapular brown adipose tissue pads of 81-day-old animals; local temperature was measured during light and dark periods between days 87 and 90. The animals were euthanized, and tissue and blood samples were collected for further analysis. The vagus and retroperitoneal sympathetic nerve activity was recorded. biResults /i/bSmall litter rats presented significant lower interscapular brown adipose tissue temperature during the light (NL 37.6°C vs. SL 37.2°C) and dark (NL 38°C vs. SL 37.6°C) periods compared to controls. Morphology of small litter brown adipose tissue showed fewer lipid droplets in the tissue center and more and larger in the periphery. The activity of vagus nerve was 19,9% greater in the small litter than in control (p0.01), and no difference was observed in the sympathetic nerve activity. In adulthood, the small litter rats were 11,7% heavier than the controls and presented higher glycemia 13,1%, insulinemia 70% and corticosteronemia 92,6%. biConclusion /i/bEarly overfeeding programming of obesity changes the interscapular brown adipose tissue structure in adulthood, leading to local thermogenesis hypoactivity, which may contribute to obesity in adults.
机译：背景/目标 棕色脂肪组织的活化被认为是一种潜在的抗肥胖机制，因为它能够通过产热来消耗能量。相反，白色脂肪组织会储存能量，从而导致肥胖。我们调查了在哺乳期通过过度喂养对肥胖进行早期编程是否会改变成年期肩s骨棕色脂肪组织的结构及其对生热的影响。 方法 产仔数被认为是第0天。在第2天，将产仔数调整为正常（9仔）和小（3仔）。在第21天，将幼仔断奶。将温度应答器植入81日龄动物的肩cap间褐色脂肪组织垫下面;在第87天到第90天之间的明暗时段测量局部温度。对动物实施安乐死，并收集组织和血液样本以进行进一步分析。记录迷走神经和腹膜后交感神经活动。 结果 小猫在光照（NL 37.6°C vs. SL 37.2°C）和黑暗（NL 38°C vs. NL）时，肩s间褐色脂肪组织的温度显着降低。 SL 37.6°C）时间段与对照相比。小棕褐色脂肪组织的形态显示，在组织中心的脂质滴较少，而在外周的脂质滴较大。在小垫料中，迷走神经的活动比对照组大19.9％（p <0.01），在交感神经活动方面没有观察到差异。成年后，幼仔大鼠比对照组重11.7％，并有较高的血糖13.1％，胰岛素血症70％和皮质酮血症92.6％。 结论 肥胖的早期过度喂养计划会改变成年期肩s骨棕色脂肪组织的结构，导致局部生热功能减退，这可能会导致成年人肥胖。

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