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首页> 外文期刊>Cellular Physiology and Biochemistry >Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer
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Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer

机译：更高数目的T-Bet +肿瘤浸润淋巴细胞与人类上皮性卵巢癌的更好生存相关

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>Background/Aims: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients and a potential biomarker for immunotherapy. In the present study, we aimed to assess the clinical significance and prognostic value of T-bet+ tumor-infiltrating lymphocytes in human epithelial ovarian cancer. Methods: The immunohistochemistry was used to analyze the infiltration density of T-bet+ lymphoid cells in human epithelial ovarian cancer tissues, and the flow cytometry analysis was used to further analyze the presence of T-bet+ tumor-infiltrating lymphocytes subgroups in cancer tissues. Results: Our immunohistochemistry analysis showed increased number of T-bet+ lymphoid cells in the human epithelial ovarian cancer tissues, and the flow cytometry analysis further demonstrated the presence of T-bet+ tumor-infiltrating lymphocytes subgroups including CD4+ , CD8+ T cells and NK cells. In addition, we also observed a significant association of T-bet+ tumor-infiltrating lymphocytes density in the tumor nest of cancer with not only serum CA125 levels but also with distant metastasis. However no association was observed with other characteristics like patients' age, pathological type, FIGO stage, tumor site and tumor size. Furthermore, the survival analysis showed that higher density of T-bet+ tumor-infiltrating lymphocytes both in tumor nest and tumor stroma of cancer tissues was significantly associated with better patient survival. In addition, the density of T-bet+ tumor-infiltrating lymphocytes in tumor nest appeared to be an independent risk factor for predicting patientsa€? postoperative prognoses. Conclusions: Our data indicated that the key transcription factor T-bet might play an important role in the type I immune cells mediated antitumor response, and the density of T-bet+ lymphocytes in human epithelial ovarian cancer tissues could serve as a prognostic predictor for ovarian cancer patients.
机译：> 背景/目的： T-bet是T-box转录因子家族的成员，是肿瘤微环境中I型免疫反应的关键标志。 ，并且先前已被我们报道为人胃癌患者的重要预后指标和免疫疗法的潜在生物标志物。本研究旨在评估T-bet + 肿瘤浸润淋巴细胞在人上皮性卵巢癌中的临床意义和预后价值。 方法： 采用免疫组化方法分析人上皮性卵巢癌组织中T-bet + 淋巴样细胞的浸润密度，并进行流式细胞仪分析。进一步分析了癌组织中T-bet + 肿瘤浸润淋巴细胞亚群的存在。 结果： 我们的免疫组织化学分析显示，人上皮性卵巢癌组织中T-bet + 淋巴样细胞数量增加，流式细胞术进一步分析证实存在T-bet + 肿瘤浸润淋巴细胞亚群，包括CD4 + ，CD8 + T细胞和NK细胞。此外，我们还观察到癌瘤巢中T-bet + 肿瘤浸润淋巴细胞的密度不仅与血清CA125水平密切相关，而且与远处转移密切相关。然而，未观察到与其他特征如患者年龄，病理类型，FIGO分期，肿瘤部位和肿瘤大小的相关性。此外，生存分析表明，癌组织的肿瘤巢和基质中T-bet + 肿瘤浸润淋巴细胞的密度较高与患者更好的生存率显着相关。另外，肿瘤巢中T-bet + 肿瘤浸润淋巴细胞的密度似乎是预测患者的独立危险因素。术后预后。 结论： 我们的数据表明关键转录因子T-bet可能在I型免疫细胞介导的抗肿瘤反应以及T-bet的密度中起重要作用。人上皮性卵巢癌组织中的sup> + 淋巴细胞可作为卵巢癌患者的预后指标。

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