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首页> 外文期刊>Cellular Physiology and Biochemistry >Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers
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Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers

机译：LncRNA PVT1的过表达预示了先进的临床病理特征，并成为胃肠道癌患者生存的不利危险因素

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>Background/Aims: Many studies have reported that PVT1 played important roles in diverse cancer types. But the systematic analysis of PVT1 in gastrointestinal cancers has not been inspected. Thus, we aimed to investigate clinical value of the long noncoding RNA PVT1 (lncRNA) expression in digestive system cancers. Methods: Eligible studies were collected from a number of databases (PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure and Wanfang database). Pooled hazard ratio (HR) or odds ratio (OR) with 95 % confidence interval (95 % Cl) were applied to assess the clinical significance of PVT1. Results: Data from 15 articles were included with a total of 2585 patients. Elevated PVT1 expression were significantly related to poor overall survival (OS) [HR = 1.86, 95% CI (1.44, 2.28); p<0. 0001] in digestive system cancers. The same association was also observed between PVT1 expression with outcomes, including disease free survival (DFS), disease specific survival (DSS) and relapse free survival (RFS). The lncRNA PVT1 could also be predicative for some clinicopathological features. Conclusions: This meta-analysis revealed that PVT1 may serve as a prognostic predictor and pathological biomarker in digestive system cancers.
机译：> 背景/目标： 许多研究报告称PVT1在多种癌症类型中起着重要作用。但是尚未检查PVT1在胃肠道癌症中的系统分析。因此，我们旨在调查长期非编码RNA PVT1（lncRNA）表达在消化系统癌症中的临床价值。 方法： 从许多数据库（PubMed，Web of Science，Embase，中国国家知识基础设施和万方数据库）收集了符合条件的研究。合并风险比（HR）或比值比（OR）和95％置信区间（95％Cl）用于评估PVT1的临床意义。 结果： 包括来自15篇文章的数据，总共2585例患者。 PVT1表达升高与总体生存率低（OS）显着相关[HR = 1.86，95％CI（1.44，2.28）; p ＜0。 [0001]在消化系统癌症中。在PVT1表达与结局之间也观察到相同的关联，包括无疾病生存期（DFS），疾病特异性生存期（DSS）和无复发生存期（RFS）。 lncRNA PVT1也可能对某些临床病理特征具有预测作用。 结论： 这项荟萃分析显示PVT1可能在消化系统癌症中作为预后指标和病理生物标志物。

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